Philippines World News API

{
    "totalArticles": 124276,
    "articles": [
        {
            "id": "1fbddf58dc6fc510062dd5a28eeccbf1",
            "title": "G894T Polymorphism (rs1799983) of the Endothelial Nitric Oxide Synthase (eNOS) Gene and Coronary Artery Disease in Cotonou (Benin)",
            "description": "Coronary artery diseases comprise a spectrum of disorders affecting the heart and blood vessels, characterized by reduced blood supply to the heart, often resulting from narrowing or obstruction of the coronary arteries. These conditions arise from an interaction between environmental and genetic factors, including the endothelial nitric oxide synthase (eNOS) gene. This study aimed to investigate the involvement of eNOS gene polymorphism in the occurrence of coronary artery disease in the Beninese population of Cotonou. An unmatched case-control observational analytical study was conducted from June to December 2019. The G894T polymorphism (rs1799983) of the eNOS gene was analyzed using the restriction fragment length polymorphism (RFLP) technique, following DNA extraction from whole blood samples. Fasting hyperglycemia was observed in 28.9% of cases compared to 2.6% of controls, and Asp298/Asp298 homozygosity was found in 7.89% of cases versus 2.63% of controls. Although the difference was not statistically significant, a trend toward an association with cardiovascular pathology was observed. This study revealed a high frequency of metabolic abnormalities in cases compared to controls and suggests a potential association between Asp298 allele homozygosity of the eNOS gene and the occurrence of cardiovascular diseases. The G894T polymorphism (rs1799983) of the eNOS gene may play a role in reducing nitric oxide bioavailability and endothelial dysfunction.",
            "content": "1. Introduction\nCardiovascular diseases, particularly coronary artery diseases, represent a major cause of mortality worldwide, with an increasing burden in low- and middle-income countries such as Benin [1] [2]. Coronary artery diseases result from ... [19191 chars]",
            "url": "https://www.scirp.org/journal/paperinformation?paperid=149094",
            "image": "https://file.scirp.org/image/ojgen2015012714031630.jpg",
            "publishedAt": "2026-01-23T06:16:51Z",
            "lang": "en",
            "source": {
                "id": "48f641eab3fd1aa330e8db4cb1cfe74e",
                "name": "SCIRP Open Access",
                "url": "https://www.scirp.org"
            }
        },
        {
            "id": "a9bd662a23013eac0022295c29b52299",
            "title": "Trump withdraws 'Board of Peace' invitation to Carney in widening rift with Canada",
            "description": "Trump said he has withdrawn the invitation to Canada to join the new Board of Peace, days after Carney warned against economic coercion by superpowers.",
            "content": "U.S. President Donald Trump withdrew the invitation to Canada to join his \"Board of Peace,\" days after Prime Minister Mark Carney's address in Davos warning against economic coersion by the world's superpowers.\n\"Dear Prime Minister Carney: Please let... [3231 chars]",
            "url": "https://www.cnbc.com/2026/01/23/trump-withdraws-board-of-peace-invitation-to-carney-in-widening-rift-with-canada.html",
            "image": "https://image.cnbcfm.com/api/v1/image/108256101-1769140375534-gettyimages-2256691370-AA_20012026_2612726.jpeg?v=1769140390&w=1920&h=1080",
            "publishedAt": "2026-01-23T05:02:04Z",
            "lang": "en",
            "source": {
                "id": "32c2ad3fb41cb87b5b847d750028dff0",
                "name": "CNBC",
                "url": "https://www.cnbc.com"
            }
        },
        {
            "id": "e01e65fd6b296673b0c7d8ec609b3228",
            "title": "A Computational Approach",
            "description": "The fruit ripening process affects the nutritional content and quality. Many fruit species have become more acceptable and present high nutritional value for animal consumption. The avocado is a fruit that produces various compounds of great significance to human nutrition, including peptides crucial to innate immunity. Avocado defensin (PaDef) is an antimicrobial peptide produced during the fruit ripening stage. Defensins have been reported to present antimicrobial activity and act as serin protease inhibitors. However, the present study found that PaDef enhanced the activity of serine proteases (which are digestive enzymes) such as trypsin and chymotrypsin, which is a new finding on the functions of plant defensin. Via the use of molecular docking assessments, the present study found that specific PaDef fragments primarily bind to the active sites of trypsin and chymotrypsin. Moreover, the stability and behavior of the peptides generated in silico from PaDef were evaluated in the presence of chymotrypsin A protease digestion using molecular dynamics simulations under basic conditions. The results obtained suggest that the selective fragments of PaDef peptides induce enzyme activity via allosteric modulation, an area of increasing research interest due to its implications for both fundamental biochemistry and applied biotechnology. The present study is a novel report on the activity of a plant defensin at a molecular level.",
            "content": "1. Introduction\nOver the course of their evolution, plants develop a fruit architecture which protects their seeds from the natural environment as part of a reproduction strategy that increases dispersal by making fruit more attractive to fauna as a ... [48517 chars]",
            "url": "https://www.scirp.org/journal/paperinformation?paperid=149083",
            "image": "https://file.scirp.org/image/ajps2024051313523682.jpg",
            "publishedAt": "2026-01-23T03:56:49Z",
            "lang": "en",
            "source": {
                "id": "48f641eab3fd1aa330e8db4cb1cfe74e",
                "name": "SCIRP Open Access",
                "url": "https://www.scirp.org"
            }
        }
    ]
}