Philippines Health News API

{
    "totalArticles": 102114,
    "articles": [
        {
            "id": "4d34fc2e31023a2a7f9a77966b6847d8",
            "title": "Decoding the neighborhood dynamics of Childhood Brain Cancer",
            "description": "New research published in Nature finds that tumor cells within supratentorial ependymomas (SE) – an aggressive childhood brain cancer – cluster into distinct tumor cell populations. Much like a neighborhood in your hometown, each cell subtype within these \"communities\" has a specific (and previously unappreciated) role to play.",
            "content": "New research published in Nature finds that tumor cells within supratentorial ependymomas (SE) – an aggressive childhood brain cancer – cluster into distinct tumor cell populations. Much like a neighborhood in your hometown, each cell subtype within ... [2627 chars]",
            "url": "https://www.news-medical.net/news/20260312/Decoding-the-neighborhood-dynamics-of-Childhood-Brain-Cancer.aspx",
            "image": "https://www.news-medical.net/image-handler/picture/2018/7/Brain_cancer%2c_3D_illustration_showing_presence_of_tumor_inside_brain_-_Kateryna_Kon_M1_6704c47fefe0477dbe1cd3351402914f-620x480.jpg",
            "publishedAt": "2026-03-12T05:18:00Z",
            "lang": "en",
            "source": {
                "id": "f2ca7a45d20357cb42858868cb4a4946",
                "name": "News-Medical",
                "url": "https://www.news-medical.net"
            }
        },
        {
            "id": "ca0264f065944d92501a04c419ffd513",
            "title": "B cell imprinting in children impairs antibodies to the haemagglutinin stalk",
            "description": "Immune imprinting1 or original antigenic sin2 is a phenomenon whereby the immune system preferentially recalls its initial response to a related, often evolving pathogen after subsequent exposure. Despite its important implications for vaccine development, the causes of imprinting remain unclear. Here, to understand the basis and impact of imprinting by influenza A viruses, we characterized the B cell responses of young children after consecutive first infections with divergent H1N1 and H3N2 strains of influenza. Children had a primary but otherwise similar B cell response to that of adults. Adult B cells commonly cross-reacted with past strains using more stereotyped and mutated immunoglobulin genes, indicating substantial homosubtypic imprinting. In children, after consecutive heterosubtypic primary infections, up to 6% of memory B cells are H1/H3 cross-reactive and bind to the highly conserved central stalk epitope—a lead target for broadly protective vaccine candidates. Over 90% of these B cells had a higher affinity for the imprinting H3N2 strain, resulting in reduced breadth and neutralization potency against H1N1 strains. Mechanistically, the imprinting H3 strains and affected H1 strains shared a residue change in the stalk epitope (D46N) that was central to the nearly universal shift in reactivity, despite differing by only a single atomic group. In conclusion, imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes. Imprinting by influenza viruses can cause a deleterious shift of nearly the entire memory recall response against key, conserved epitopes.",
            "content": "Human samples\nSerum and peripheral blood mononuclear cell (PBMC) samples were obtained from participants enrolled in two prospective community-based studies in Nicaragua: The Household Influenza Transmission Study (HITS) and the Nicaraguan Pediatric ... [41047 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10248-6?error=cookies_not_supported&code=31f8f134-97c7-4008-86db-ec4f76fd2f03",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10248-6/MediaObjects/41586_2026_10248_Fig1_HTML.png",
            "publishedAt": "2026-03-11T22:51:21Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "2d26979f1c575aaec1f96761ead64101",
            "title": "Multidimensional profiling of heterogeneity in supratentorial ependymomas",
            "description": "Supratentorial ependymomas are aggressive childhood brain cancers that retain features of neurodevelopmental cell types1 and segregate into molecularly and clinically distinct subgroups2,3, suggesting different developmental roots. The developmental signatures, as well as microenvironmental factors, underlying aberrant cellular transformation and behaviour across each supratentorial ependymoma subgroup are unclear. Here we integrated single-cell and spatial transcriptomics, as well as in vitro and in vivo live-cell imaging, to define supratentorial ependymoma cell states, spatial organization and dynamic behaviour within the neural microenvironment. We find that individual tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation. We further identify several modes of spatial organization of these tumours, including a high-order architecture that is influenced by mesenchymal and hypoxia signatures, and local neighbourhood structures. Finally, we identify a role for brain-resident cells in shifting supratentorial ependymoma cellular heterogeneity towards neuronal-like cells that co-opt immature neuronal morphology and migratory mechanisms, and a subset of neuroepithelial-like cells that are both proliferative and highly migratory. Collectively, these findings provide a multidimensional framework to integrate transcriptional and phenotypic characterization of tumour heterogeneity in supratentorial ependymoma and its potential clinical implications. Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.",
            "content": "Experimental model and participant details\nHuman participants\nAll of the deidentified samples used in this study were obtained after informed consent of patients and/or their legal representatives who did not receive compensation. The study was appro... [44015 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10214-2?error=cookies_not_supported&code=b068caee-205c-4135-801d-59c63ad48cac",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10214-2/MediaObjects/41586_2026_10214_Fig1_HTML.png",
            "publishedAt": "2026-03-11T21:56:15Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        }
    ]
}