Philippines Health News API

{
    "totalArticles": 106128,
    "articles": [
        {
            "id": "64ad3a6d14d205e349f6e5dc4338535b",
            "title": "Estradiol patches as effective as injections for locally advanced prostate cancer",
            "description": "Hormone patches are as good at controlling locally advanced prostate cancer as the injections typically used to deliver hormone therapy, according to the results of a large clinical trial led by UCL (University College London) researchers.",
            "content": "Hormone patches are as good at controlling locally advanced prostate cancer as the injections typically used to deliver hormone therapy, according to the results of a large clinical trial led by UCL (University College London) researchers.\nMen with c... [7331 chars]",
            "url": "https://www.news-medical.net/news/20260325/Estradiol-patches-as-effective-as-injections-for-locally-advanced-prostate-cancer.aspx",
            "image": "https://www.news-medical.net/images/tags/TagImage-2099-458520524366319441723-620x480.jpg",
            "publishedAt": "2026-03-26T02:56:00Z",
            "lang": "en",
            "source": {
                "id": "f2ca7a45d20357cb42858868cb4a4946",
                "name": "News-Medical",
                "url": "https://www.news-medical.net"
            }
        },
        {
            "id": "11de29f11c7f3a4c255c549a9453702f",
            "title": "Parasites trigger epithelial cell crosstalk to drive gut-brain signalling",
            "description": "Parasitic infections modulate both immune and sensory responses, but how these systems collaborate to elicit protective behaviours remains incompletely understood. The gut epithelium contains specialized sensory cells that detect pathogens and irritants. These include cholinergic tuft cells, which sense parasites and initiate type 2 immune responses1–3, as well as serotonergic enterochromaffin (EC) cells, which detect irritants and communicate with afferent nerve fibres to transmit nociceptive signals4–6. Here we show that paracrine signalling between these cells constitutes a mechanism for neuro–immune interaction and gut–brain communication. We find that tuft cells use two distinct mechanisms of acetylcholine (ACh) release despite lacking synaptic vesicles and excitable membranes. These include acute release in response to parasite-derived metabolites, followed by constitutive ‘leak-like’ release, which occurs with type 2 inflammation. Although both mechanisms can activate muscarinic receptors on crypt-residing EC cells, only the sustained mode of ACh release elicits levels of serotonin sufficient to stimulate vagal afferent neurons that suppress food intake. This two-phase paracrine signalling mechanism explains how parasitic infection progresses from an initial asymptomatic phase to symptomatic established disease, in which type 2 immune and sensory signalling pathways within the gut–brain axis collaborate to evoke protective behaviours. Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occurs during parasite infections.",
            "content": "Mice\nAll experimental procedures were conducted in accordance with guidelines approved by the Institutional Animal Care Committees at the University of California, San Francisco (UCSF) and the South Australian Health and Medical Research Institute (S... [37187 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10281-5?error=cookies_not_supported&code=384c3a22-d84f-423a-94b0-050af84be3a5",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10281-5/MediaObjects/41586_2026_10281_Fig1_HTML.png",
            "publishedAt": "2026-03-25T22:18:45Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "62217954343f1f64a64ced9d3d40790d",
            "title": "GloraMD Liquid Solution: A New Approach to Smoother, Firmer-Looking Skin with Glora MD Serum",
            "description": "Explore GloraMD Liquid Solution, GloraMD serum, GloraMD solution including how it works, its ingredients, and important factors to consider before use.",
            "content": "Explore GloraMD Liquid Solution, GloraMD serum, GloraMD solution including how it works, its ingredients, and important factors to consider before use.\nNew York City, NY, March 25, 2026 (GLOBE NEWSWIRE) --\nIntroduction\nIn today’s skincare landscape, ... [16108 chars]",
            "url": "https://www.manilatimes.net/2026/03/26/tmt-newswire/globenewswire/gloramd-liquid-solution-a-new-approach-to-smoother-firmer-looking-skin-with-glora-md-serum/2307895",
            "image": "https://www.manilatimes.net/manilatimes/uploads/images/2026/03/26/988618.png",
            "publishedAt": "2026-03-25T19:43:22Z",
            "lang": "en",
            "source": {
                "id": "e3ad8bbf7dbe3c3defc56a8393455066",
                "name": "The Manila Times",
                "url": "https://www.manilatimes.net"
            }
        }
    ]
}