Philippines Health News API

{
    "totalArticles": 102044,
    "articles": [
        {
            "id": "2d26979f1c575aaec1f96761ead64101",
            "title": "Multidimensional profiling of heterogeneity in supratentorial ependymomas",
            "description": "Supratentorial ependymomas are aggressive childhood brain cancers that retain features of neurodevelopmental cell types1 and segregate into molecularly and clinically distinct subgroups2,3, suggesting different developmental roots. The developmental signatures, as well as microenvironmental factors, underlying aberrant cellular transformation and behaviour across each supratentorial ependymoma subgroup are unclear. Here we integrated single-cell and spatial transcriptomics, as well as in vitro and in vivo live-cell imaging, to define supratentorial ependymoma cell states, spatial organization and dynamic behaviour within the neural microenvironment. We find that individual tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation. We further identify several modes of spatial organization of these tumours, including a high-order architecture that is influenced by mesenchymal and hypoxia signatures, and local neighbourhood structures. Finally, we identify a role for brain-resident cells in shifting supratentorial ependymoma cellular heterogeneity towards neuronal-like cells that co-opt immature neuronal morphology and migratory mechanisms, and a subset of neuroepithelial-like cells that are both proliferative and highly migratory. Collectively, these findings provide a multidimensional framework to integrate transcriptional and phenotypic characterization of tumour heterogeneity in supratentorial ependymoma and its potential clinical implications. Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.",
            "content": "Experimental model and participant details\nHuman participants\nAll of the deidentified samples used in this study were obtained after informed consent of patients and/or their legal representatives who did not receive compensation. The study was appro... [44015 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10214-2?error=cookies_not_supported&code=b068caee-205c-4135-801d-59c63ad48cac",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10214-2/MediaObjects/41586_2026_10214_Fig1_HTML.png",
            "publishedAt": "2026-03-11T21:56:15Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "7069f88ad914fd25bb4c8fc737b5dfe5",
            "title": "New Study Shows the Life-Changing Power of Cognitive Behavioral Therapy-Based Youth Mentoring",
            "description": "Controlled trial confirms YMCA’s Reach & Rise program, founded in San Francisco 34 years ago, reduces youth delinquency and substance abuse; improves school and family connectedness",
            "content": "Controlled trial confirms YMCA’s Reach & Rise program, founded in San Francisco 34 years ago, reduces youth delinquency and substance abuse; improves school and family connectedness\nSan Francisco, California, March 11, 2026 (GLOBE NEWSWIRE) -- March ... [5714 chars]",
            "url": "https://www.manilatimes.net/2026/03/12/tmt-newswire/globenewswire/new-study-shows-the-life-changing-power-of-cognitive-behavioral-therapy-based-youth-mentoring/2298331",
            "image": "https://www.manilatimes.net/manilatimes/uploads/images/2026/03/12/969718.jpg",
            "publishedAt": "2026-03-11T21:12:51Z",
            "lang": "en",
            "source": {
                "id": "e3ad8bbf7dbe3c3defc56a8393455066",
                "name": "The Manila Times",
                "url": "https://www.manilatimes.net"
            }
        },
        {
            "id": "75e584cd34e2bb0b2d7904275cd9cd31",
            "title": "Severe COVID-19 Infections May Prime the Lung for Cancer Growth",
            "description": "Study shows severe COVID-19 infections can reprogram lung immunity, creating lasting inflammatory changes that accelerate lung cancer growth.",
            "content": "A new study published in Cell suggests that severe viral pneumonia—including severe COVID-19—may leave behind lasting changes in the lung that increase the risk of future lung cancer or accelerate tumor growth if cancer emerges.\nThe research, led by ... [6350 chars]",
            "url": "https://www.insideprecisionmedicine.com/topics/oncology/severe-covid-19-infections-may-prime-the-lung-for-cancer-growth/",
            "image": "https://www.insideprecisionmedicine.com/wp-content/uploads/2021/06/May1_20221_GettyImages_1209209980_CoronavirusWorldMapLungs-scaled.jpg",
            "publishedAt": "2026-03-11T17:34:02Z",
            "lang": "en",
            "source": {
                "id": "109f786697844947c1fdd219350f1b78",
                "name": "Inside Precision Medicine",
                "url": "https://www.insideprecisionmedicine.com"
            }
        }
    ]
}