Philippines Health News API

{
    "totalArticles": 110128,
    "articles": [
        {
            "id": "80045d868f26f6ae0761baa2d12fb1ec",
            "title": "β-Arrestin condensates regulate G-protein-coupled receptor function",
            "description": "β-Arrestins 1 and 2 are multifunctional adaptor proteins1 that regulate the signalling of G-protein-coupled receptors (GPCRs), the largest class of receptors, which impact nearly all aspects of physiology and are one of the most common drug targets2. Although β-arrestins interact with a wide array of signalling effectors at many GPCRs, it is unclear how β-arrestins promote such varied functions. Here we show that β-arrestins undergo liquid–liquid phase separation, forming condensates that regulate GPCR function. We show that condensation is specific to visual arrestins and β-arrestins, and demonstrate that β-arrestin oligomerization occurs in proximity to the GPCR to regulate GPCR functions such as internalization and signalling. Our work provides a paradigm for β-arrestin condensates as regulators of GPCR function, with liquid–liquid phase separation serving as an important promoter of signalling compartmentalization at GPCRs. β-Arrestins, multifunctional adaptor proteins that regulate G-protein-coupled receptors (GPCRs), form phase-separated condensates, suggesting that β-arrestin liquid–liquid phase separation organizes and diversifies GPCR signalling functions.",
            "content": "To test for the ability of β-arrestins to oligomerize when overexpressed, we compared patterns of β-arrestin labelling with monomeric and split GFP variants. Labelling of β-arrestins with enhanced GFP (eGFP) on the C terminus of β-arrestin 1 or 2 dem... [26481 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10539-y?error=cookies_not_supported&code=ee9193a3-c575-4054-9430-213437832522",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10539-y/MediaObjects/41586_2026_10539_Fig1_HTML.png",
            "publishedAt": "2026-05-27T19:14:35Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "411aeccc6e21ecdc3a7ab224f5efc5b3",
            "title": "Virtual reality navigation deficits predict future brain volume loss",
            "description": "Alzheimer's disease (AD) often begins long before it is clinically recognized, with subtle brain changes emerging years before noticeable memory loss or cognitive decline.",
            "content": "Alzheimer's disease (AD) often begins long before it is clinically recognized, with subtle brain changes emerging years before noticeable memory loss or cognitive decline. Among the earliest regions affected are the hippocampus and entorhinal cortex,... [4010 chars]",
            "url": "https://www.news-medical.net/news/20260527/Virtual-reality-navigation-deficits-predict-future-brain-volume-loss.aspx",
            "image": "https://www.news-medical.net/image-handler/picture/2016/2/Alzheimers_amyloid_plaque_-_Juan_Gaertner_9638f1223d534b518a192c8478871d65-620x480.jpg",
            "publishedAt": "2026-05-27T15:57:00Z",
            "lang": "en",
            "source": {
                "id": "f2ca7a45d20357cb42858868cb4a4946",
                "name": "News-Medical",
                "url": "https://www.news-medical.net"
            }
        },
        {
            "id": "15bd80a63871f1fa9fed71a2580e34a3",
            "title": "5 Nutrition-Boosting Tips to Spread Protein Throughout the Day",
            "description": "NEW YORK, May 27, 2026 (GLOBE NEWSWIRE) -- (Feature Impact) Most Americans are eating enough protein. They’re just eating it wrong.",
            "content": "NEW YORK, May 27, 2026 (GLOBE NEWSWIRE) -- (Feature Impact) Most Americans are eating enough protein. They’re just eating it wrong.\nA Media Snippet accompanying this announcement is available by clicking on this link.\nProtein is the macronutrient of ... [4720 chars]",
            "url": "https://www.manilatimes.net/2026/05/27/tmt-newswire/globenewswire/5-nutrition-boosting-tips-to-spread-protein-throughout-the-day/2352998",
            "image": "https://cdnx.premiumread.com/?url=https://www.manilatimes.net/theme_manilatimes/images/TMT_1920x1008.jpg&w=1920&q=100&f=webp&v=1",
            "publishedAt": "2026-05-27T15:54:30Z",
            "lang": "en",
            "source": {
                "id": "e3ad8bbf7dbe3c3defc56a8393455066",
                "name": "The Manila Times",
                "url": "https://www.manilatimes.net"
            }
        }
    ]
}