Singapore News API

{
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        {
            "id": "3ad8708c4eb4a855a557af9713a3d3b7",
            "title": "Major depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases",
            "description": "Major depressive disorder (MDD) is a prevalent neuropsychiatric disorder associated with significant morbidity and mortality. Increasing evidence suggests that a subset of MDD patients exhibit a dysregulated immune system. However, few clinical studies have tested the efficacy of anti-inflammatory drugs in reducing symptoms of depression. In contrast, targeted immunomodulatory drugs have revolutionized the treatment of inflammatory skin disorders, such as atopic dermatitis (AD) and psoriasis. To assess the viability of a targeted treatment approach in MDD, we first compared the blood proteomic profiles of patients with MDD to those of patients with AD, psoriasis, and healthy controls (HCs). We demonstrated that the proteomic signatures of MDD patients share Th2 skewing and dysregulation of other immune/neurovascular-related proteins with AD. Next, we performed an in-silico drug repurposing analysis to test whether common biologics used in dermatology could also affect the dysregulated proteomic signature observed in MDD patients. This computational approach identified dupilumab, which targets the IL-4 receptor α subunit (IL-4Rα) and thus inhibits the Th2 axis, as significantly affecting the MDD signature by reversing the dysregulation of several inflammatory proteins related to Th2 signaling. Finally, in a mouse model of chronic social defeat stress (CSDS), we showed that pharmacological inhibition of IL-4Rα prevented stress-induced social avoidance behavior. Our findings underscore the potential role of the Th2 axis in MDD, highlighting the potential of specifically targeting Th2 as a disease-modifying treatment. Additionally, the back-translational drug repurposing strategy employed in this study may offer a novel approach to identify immunomodulatory drugs in psychiatry.",
            "content": "Lee B, Wang Y, Carlson SA, Greenlund KJ, Lu H, Liu Y, et al. National, state-level, and county-level prevalence estimates of adults aged >/=18 years self-reporting a lifetime diagnosis of depression - United States, 2020. MMWR Morb Mortal Wkly Rep. 2... [20161 chars]",
            "url": "https://www.nature.com/articles/s41380-025-03383-5?error=cookies_not_supported&code=ffc36545-0a88-44b6-8dc4-919ef5c74084",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41380-025-03383-5/MediaObjects/41380_2025_3383_Fig1_HTML.png",
            "publishedAt": "2026-02-11T09:18:55Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "964a27863ded31b818da65c52b2cb448",
            "title": "Inside President Xi’s renewed push for yuan to be a global reserve currency - what China would have to give up",
            "description": "A revived speech and a shifting global backdrop. Beijing is signalling new urgency in its push to elevate the yuan - but the trade-offs remain unresolved, analysts say.",
            "content": "SHANGHAI: Chinese President Xi Jinping wants the yuan to become a global reserve currency - one that central banks hold in significant quantities, a role which the US dollar has dominated since the Second World War.\nThe ambition is not new. China lau... [10462 chars]",
            "url": "https://www.channelnewsasia.com/east-asia/xi-jinping-yuan-currency-us-dollar-china-5920046",
            "image": "https://dam.mediacorp.sg/image/upload/s--jALON-6d--/c_fill,g_auto,h_676,w_1200/fl_relative,g_south_east,l_mediacorp:cna:watermark:2024-04:reuters_1,w_0.1/f_auto,q_auto/v1/one-cms/core/2025-10-27T011414Z_1_LYNXMPEL9Q018_RTROPTP_3_GLOBAL-FOREX.JPG?itok=UcEBcaDi",
            "publishedAt": "2026-02-11T08:52:57Z",
            "lang": "en",
            "source": {
                "id": "08538e21f9ef4fd994fa94c90374f079",
                "name": "CNA",
                "url": "https://www.channelnewsasia.com"
            }
        },
        {
            "id": "be597861f856b2121a7cb25a2761b077",
            "title": "Father of 6-year-old killed in Chinatown accident offered free accommodation in S’pore by Ascott",
            "description": "Ascott provides complimentary accommodation to the father of a six-year-old killed in a Chinatown accident, supporting him while his wife receives medical care. Read more at straitstimes.com.",
            "content": "SINGAPORE – Hotel operator Ascott has offered complimentary accommodation to the father of six-year-old Sheyna Lashira Smaradiani, who\ndied after a car accident in Chinatown on Feb 6.\n“Our hearts go out to Mr Ashar Ardianto and his family following t... [1930 chars]",
            "url": "https://www.straitstimes.com/singapore/hotel-chain-ascott-offers-accommodation-to-family-of-6-year-old-killed-in-chinatown-accident",
            "image": "https://cassette.sphdigital.com.sg/image/straitstimes/84ccdec2bf361b3756642d160cf526fd29cfa2032621aebe080ccf448d0cc78e",
            "publishedAt": "2026-02-11T08:47:15Z",
            "lang": "en",
            "source": {
                "id": "739b615c65becd670ee152cab7f8c439",
                "name": "The Straits Times",
                "url": "https://www.straitstimes.com"
            }
        }
    ]
}