Philippines Business News API

{
    "totalArticles": 282112,
    "articles": [
        {
            "id": "38b04a591454c276cd1c0f9e87df85ff",
            "title": "Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 signaling pathway",
            "description": "Exposure to zearalenone (ZEN), an estrogen-like mycotoxin produced by Fusarium fungi, impairs reproductive performance and farm-animal welfare; however, the underlying mechanism remains unclear. Using female pigs as the large animal model, we demonstrate that ZEN-induced reproductive lipotoxicity is associated with alterations in estrogen receptor-alpha (ERα) expression, diacylglycerol levels, and pro-inflammatory cytokine production. Mechanistically, upregulated ERα directly binds to the promoter regions of Cd36 and Tlr4 in the nucleus, leading to increased expression of the lipid transporter CD36 and the inflammatory receptor TLR4, as well as enhanced CD36-TLR4 interaction. This subsequently results in diacylglycerol accumulation and inflammation. Consistently, studies using Cd36-knockout mice and the TLR4-specific inhibitor TAK-242 reveal that ZEN-induced reproductive lipotoxicity is dependent on the ERα-CD36/TLR4 axis. Furthermore, dietary supplementation with the ZEN-degrading enzyme ZLHY-6 in female pigs also counteracts ZEN-induced reproductive lipotoxicity through the inhibition of the ERα-CD36/TLR4 signaling pathway. Together, these findings reveal a novel mechanism underlying ZEN-induced reproductive lipotoxicity, and highlight the ERα-CD36/TLR4 axis as a potential therapeutic target. Mechanistic investigation of zearalenone-induced reproductive lipotoxicity identifies the ERα-CD36/TLR4 axis as a key mediator and therapeutic target.",
            "content": "Eskola, M. et al. Worldwide contamination of food-crops with mycotoxins: validity of the widely cited ‘FAO estimate’of 25%. Crit. Rev. Food Sci. Nutr. 60, 2773–2789 (2020).\nLiu, J. & Applegate, T. Zearalenone (ZEN) in Livestock and Poultry: Dose, tox... [5709 chars]",
            "url": "https://www.nature.com/articles/s42003-026-09953-9?error=cookies_not_supported&code=147c27ca-f1c3-4314-804b-7a083a74b8eb",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs42003-026-09953-9/MediaObjects/42003_2026_9953_Figa_HTML.png",
            "publishedAt": "2026-04-10T03:08:09Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "43bfabafaed2ca1a5b330122149490bd",
            "title": "Stocks rally on optimism over Iran war ceasefire, oil extends gains",
            "description": "Stocks rose Friday with investors still optimistic about the shaky ceasefire in the US-Iran war ahead of planned weekend talks, though oil prices extended gains over worries Israel's continued attacks…",
            "content": "Washington and Tehran's announcement Tuesday of a two-week truce that would see the Strait of Hormuz reopened, having been closed since the start of the war, sparked a wave of euphoria across markets.\nBut hopes for an end to the crisis have been hit ... [3701 chars]",
            "url": "https://www.france24.com/en/live-news/20260410-stocks-rally-on-optimism-over-iran-war-ceasefire-oil-extends-gains",
            "image": "https://s.france24.com/media/display/ce63d286-3489-11f1-8567-005056a90284/w:1280/p:16x9/b13396b1e6650c6291f047291a3587a9a47a5465.jpg",
            "publishedAt": "2026-04-10T03:03:11Z",
            "lang": "en",
            "source": {
                "id": "f501fcfec9884d330bc84a73998805a5",
                "name": "France 24",
                "url": "https://www.france24.com"
            }
        },
        {
            "id": "f174f01a80ee0c135690d2650665bfd3",
            "title": "JGSOM Finance and Accounting Faculty Participate in 6th Annual FutureCFO Conference Philippines 2026",
            "description": "Quezon City, Philippines — March 19, 2026 — Faculty members from the Finance and Accounting Department of the John Gokongwei School of Management (JGSOM), Ateneo de Manila University, actively participated in the 6th Annual FutureCFO Conference Philippines 2026 held at the New World Hotel. The conference was organized and hosted by CXOCIETY, bringing together finance leaders, practitioners, and academics to discuss emerging trends and challenges shaping the future of the finance function.",
            "content": "Quezon City, Philippines — March 19, 2026 — Faculty members from the Finance and Accounting Department of the John Gokongwei School of Management (JGSOM), Ateneo de Manila University, actively participated in the 6th Annual FutureCFO Conference Phili... [1783 chars]",
            "url": "https://www.ateneo.edu/news/2026/04/jgsom-finance-accounting-faculty-participate-6th-annual-futurecfo-conference",
            "image": "http://www.ateneo.edu/sites/default/files/2026-04/IMG_1131_resized.jpg",
            "publishedAt": "2026-04-10T00:47:24Z",
            "lang": "en",
            "source": {
                "id": "7bad6131561d1de7d2ea0e80eb468424",
                "name": "Ateneo de Manila University",
                "url": "https://www.ateneo.edu"
            }
        }
    ]
}