Pakistan Science News API

{
    "totalArticles": 23360,
    "articles": [
        {
            "id": "ce8b261868f8e6641fc89eb4795c7732",
            "title": "Large, aggressive 'hulk' lizards wipe out millions of years of species evolution",
            "description": "A recent study examined the rapid evolutionary displacement of color morphs in Mediterranean wall lizards, highlighting the swift changes in species makeup.",
            "content": "After millions of years of stable gene expression and evenly distributed variations, the Mediterranean wall lizard is exhibiting a rapid flattening of traits, ScienceDaily reported.\nPodarcis muralis, often known simply as the common wall lizard, typi... [2027 chars]",
            "url": "https://www.thecooldown.com/outdoors/mediterranean-wall-lizards-rapid-evolutionary-changes/",
            "image": "https://www.thecooldown.com/wp-content/uploads/2026/04/hulklizard.jpeg",
            "publishedAt": "2026-04-28T02:00:00Z",
            "lang": "en",
            "source": {
                "id": "e1ead52d96666e44f50f0649131c4e28",
                "name": "The Cool Down",
                "url": "https://www.thecooldown.com"
            }
        },
        {
            "id": "a8583d2439114b4a0baf81b3f8347310",
            "title": "ALMA Witnesses Star Birth Beyond the Milky Way",
            "description": "Highlights Astronomers have used the Atacama Large Millimeter/submillimeter Array (ALMA) to map, for the first time, the mass distribution of the gas and dust clumps from which new stars are born—the so-called core mass function (CMF)—in a star-forming region outside the Milky Way. The study, led by the Italian National Institute for Astrophysics and published...",
            "content": "Scientific Paper\nHighlights\nALMA has enabled the first measurement of the core mass function in a galaxy beyond the Milky Way\nObservations of the Large Magellanic Cloud show that star-forming cores follow similar patterns to those in our Galaxy\nThe r... [5086 chars]",
            "url": "https://www.almaobservatory.org/en/press-releases/alma-witnesses-star-birth-beyond-the-milky-way/",
            "image": "https://www.almaobservatory.org/wp-content/uploads/2026/04/image-2.png",
            "publishedAt": "2026-04-27T22:20:41Z",
            "lang": "en",
            "source": {
                "id": "b631aaddf464c0a2a3a682954851141a",
                "name": "ALMA Observatory",
                "url": "https://www.almaobservatory.org"
            }
        },
        {
            "id": "c2de69324762b570dcc9deecea364ead",
            "title": "Nuclease-NTPase antiphage defence systems use conserved molecular features to control bacterial immunity",
            "description": "Bacteria encode diverse defence systems, including restriction–modification and CRISPR–Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence operons comprise a nuclease and NTPase protein, suggesting that additional nucleic acid-targeting systems remain to be understood. Here we develop large-scale comparative cell biology and biochemical approaches to analyse 16 nuclease–NTPase systems and define molecular features that control antiphage defence. Purification, biochemical characterization and in vitro reconstitution of nucleic acid degradation demonstrates that protein–protein complex formation is a shared feature of multigene nuclease–NTPase systems. We show that PaAbpAB, BtHachiman and EcPD-T4-8 system nucleases use highly degenerate recognition site preferences to enable broad nucleic acid degradation, and the Azaca system exhibits specific phage targeting through the recognition of modified phage genomic DNA. Our results uncover principles of antiphage defence system function and highlight the mechanistic diversity of nuclease–NTPase systems in bacterial immunity. A large-scale, comparative cell biology and biochemical screen defines the molecular features controlling antiphage defence systems that encode nuclease effectors and accessory NTPase proteins.",
            "content": "Roberts, R. J. et al. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res. 31, 1805–1812 (2003).\nLoenen, W. A. M., Dryden, D. T. F., Raleigh, E. A., Wilson, G. G. & Murray, N. E. Hig... [9253 chars]",
            "url": "https://www.nature.com/articles/s41564-026-02312-8?error=cookies_not_supported&code=036a258d-e3e8-4aea-b6ed-85c515329719",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41564-026-02312-8/MediaObjects/41564_2026_2312_Fig1_HTML.png",
            "publishedAt": "2026-04-27T22:07:30Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        }
    ]
}