Pakistan Science News API

{
    "totalArticles": 17462,
    "articles": [
        {
            "id": "dc924dcf16bb425d3688900131bd9bc0",
            "title": "MS Analysis Reveals Phytochemical Differences in Ashwagandha Root Extracts from Egypt and India",
            "description": "Researchers conducted a detailed analysis comparing the […]",
            "content": "GC-MS Analysis Reveals Phytochemical Differences in Ashwagandha Root Extracts from Egypt and India\nResearchers conducted a detailed analysis comparing the chemical compositions of ashwagandha root extracts from Egypt and India using gas chromatograph... [1071 chars]",
            "url": "https://www.geneonline.com/gc-ms-analysis-reveals-phytochemical-differences-in-ashwagandha-root-extracts-from-egypt-and-india/",
            "image": "https://www.geneonline.com/wp-content/uploads/EN_NEWSFLASH_5-1.png",
            "publishedAt": "2025-11-22T01:36:52Z",
            "lang": "en",
            "source": {
                "id": "e5376462a7128acdb762718aa2daf90e",
                "name": "geneonline.com",
                "url": "https://www.geneonline.com"
            }
        },
        {
            "id": "fc9f789465d8c7a0b971c245ebb2f41b",
            "title": "Loss of retinal stem cell reserve and lipofuscin accumulation accelerates cone-rod degeneration and replicates Stargardt disease in abca4b null zebrafish",
            "description": "Mutations in ABCA4 gene causes Stargardt macular degeneration, which manifests with toxic lipofuscin deposits in the outer retina, gradual atrophy of RPE cells, followed by photoreceptor cell loss. The cone-enriched retina, with macula-like ‘area-temporalis’ of zebrafish are better models than rodents for studying human macular dystrophies. Here, we generated abca4b knockout zebrafish model using CRISPR/Cas9 editing and evaluated the early and late-stage retinal changes. In adult abca4b−/− mutants, the RPE cells exhibited hyperpigmentation, altered retinomotor behaviour and lipofuscin accumulation, but they remained viable. However, the photoreceptors underwent progressive degeneration, with a sequential loss of blue and UV cones, followed by red and green cones and finally the rod cells. This triggered the chronic activation and early depletion of retinal stem cells at the ciliary marginal zone of mutants and resulted in accelerated outer-retinal degeneration and severe visual defects, despite them retaining the Müller glia-dependant retinal repair potential.",
            "content": "Chen, T. C. et al. Genetic characteristics and epidemiology of inherited retinal degeneration in Taiwan. NPJ Genom Med. 6, 16. https://doi.org/10.1038/s41525-021-00180-1 (2021).\nCornelis, S. S. et al. Compendium of Clinical Variant Classification for... [8983 chars]",
            "url": "https://www.nature.com/articles/s41598-025-28951-1?error=cookies_not_supported&code=bf406fc2-b61e-437e-a909-a334ce6161f0",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2025-11-21T18:14:44Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "6ad7326817dabb12483371e26de76e9f",
            "title": "NASA astronaut shows how to 'weigh' yourself in space | On the ISS this week Nov. 17-21, 2025",
            "description": "From measuring one's mass to boosting the almost 1 million pounds that comprise the entire orbiting complex, the Expedition 73 crew aboard the International Space Station had a busy week in orbit.",
            "content": "From measuring one's mass to boosting the almost 1 million pounds (454,000 kilograms) that comprise the entire orbiting complex, the Expedition 73 crew aboard the International Space Station had a busy week in Earth orbit.\nOrbital observation\nIt's a ... [3712 chars]",
            "url": "https://www.space.com/space-exploration/international-space-station/nasa-astronaut-shows-how-to-weigh-yourself-in-space-on-the-iss-this-week-nov-17-21-2025",
            "image": "https://cdn.mos.cms.futurecdn.net/xxPrJP5NjXPvXi2W2T7rVJ-1920-80.jpg",
            "publishedAt": "2025-11-21T17:00:00Z",
            "lang": "en",
            "source": {
                "id": "024dd4370bda9e6e6791231c2a935d20",
                "name": "Space",
                "url": "https://www.space.com"
            }
        }
    ]
}