Pakistan Business News API

{
    "totalArticles": 351154,
    "articles": [
        {
            "id": "74272229de70f86596046b0f583ffb1b",
            "title": "Integrative ensemble learning framework for forecasting controlled drug release based on Raman spectral signatures",
            "description": "Modeling drug-release kinetics from polysaccharide-coated oral controlled-release formulations remains challenging due to nonlinear diffusion–dissolution behavior, complex polymer–drug interactions, and the limited interpretability of conventional machine-learning approaches. In this study, we develop and validate a predictive framework for targeted colonic delivery of 5-aminosalicylic acid (5-ASA) from polysaccharide-coated solid oral dosage forms using Raman spectroscopy–derived molecular fingerprints and time-resolved dissolution data. The dataset comprises 155 formulation samples, each characterized by more than 1,500 Raman spectral features, categorical formulation variables (polysaccharide type and release medium), and drug-release measurements at 2, 8, and 24 h collected under simulated physiological conditions. A dual-optimizer, dual-ensemble learning strategy is introduced, integrating the Puma Optimizer Algorithm (POA) and Black-Winged Kite Algorithm (BWKA) within a Damsphere Weighted Ensemble (DWE) of XGBoost regression and AdaBoost models. The complementary exploration–exploitation dynamics of the two optimizers enhance convergence stability and generalization, yielding strong predictive performance under five-fold cross-validation (RMSE = 0.038; R2 = 0.991). Feature-level analysis based on F-statistics highlights release time, dissolution medium, and chemically meaningful Raman bands as dominant predictors, consistent with diffusion- and erosion-controlled release mechanisms in polysaccharide-coated systems. From a pharmaceutical perspective, the proposed framework reduces experimental burden while maintaining mechanistic interpretability, supporting Quality by Design (QbD) and green pharmaceutics principles. Owing to its modular architecture, the approach is readily extensible to other polymer-based oral controlled-release formulations and spectroscopic modalities.",
            "content": "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original... [625 chars]",
            "url": "https://www.nature.com/articles/s41598-026-41837-0?error=cookies_not_supported&code=1ac16517-16a4-47ac-8a65-a62e74b5c0b1",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-02-28T22:03:17Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "a9135fd0369e7924d380c21744b6d047",
            "title": "Discover How the IATA 2026 Diversity Awards Are Shaping Culturally Aware Airlines and More Welcoming Journeys for Global Travellers in Brazil",
            "description": "IATA 2026 Diversity Awards celebrate inclusive aviation, shaping global travel with richer cultural experiences and welcoming journeys for all tourists.",
            "content": "Discover How the IATA 2026 Diversity Awards Are Shaping Culturally Aware Airlines and More Welcoming Journeys for Global Travellers in Brazil\nThe IATA 2026 Diversity Awards are redefining how airlines connect cultures and travellers worldwide. These ... [5092 chars]",
            "url": "https://www.travelandtourworld.com/news/article/discover-how-the-iata-2026-diversity-awards-are-shaping-culturally-aware-airlines-and-more-welcoming-journeys-for-global-travellers-in-brazil/",
            "image": "https://www.travelandtourworld.com/wp-content/uploads/2026/03/10novf7.jpeg",
            "publishedAt": "2026-02-28T21:25:05Z",
            "lang": "en",
            "source": {
                "id": "1cbffab9ade94d830ac7fbb7c9713f30",
                "name": "Travel And Tour World",
                "url": "https://www.travelandtourworld.com"
            }
        },
        {
            "id": "cc3b1a70b37cbafcb6c6c326306c6353",
            "title": "Govt hikes petrol price by Rs8, high-speed diesel by Rs5",
            "description": "After the increase, the price of petrol has jumped from Rs258.17 to Rs266.17 while high-speed diesel's price now stands at 280.86.",
            "content": "The government on Saturday raised the price of petrol by Rs8 per litre and that of high-speed diesel (HSD) by Rs5.16 per litre for the next fortnight, according to a press release issued by the Petroleum Division.\nFollowing the increase, the price of... [763 chars]",
            "url": "https://www.dawn.com/news/1976674",
            "image": "https://i.dawn.com/large/2026/03/01000945b3c2eed.webp",
            "publishedAt": "2026-02-28T19:10:22Z",
            "lang": "en",
            "source": {
                "id": "e7c51bc1b8daaa70cfd1f48e936fcc2b",
                "name": "Dawn",
                "url": "https://www.dawn.com"
            }
        }
    ]
}