Pakistan Business News API

{
    "totalArticles": 337142,
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        {
            "id": "9c99f0b8fde285718a909c95bac798b0",
            "title": "Cell-type-resolved genetic variation shapes inflammatory bowel disease risk",
            "description": "Most genetic variants associated with complex diseases lie in non-coding regions1, complicating efforts to identify effector genes and relevant cell types. Here we map cis-expression quantitative trait loci (eQTLs) across 2.2 million single cells using intestinal biopsies and blood from 421 individuals, including 125 with inflammatory bowel disease (IBD). Cell-type-level eQTLs were more distal to transcription start sites, enriched in enhancers, less likely to regulate the nearest gene, and more than 3.5-fold more likely to colocalize with IBD loci detected in genome-wide association studies (GWASs) than eQTLs detected at tissue-level resolution. We nominate effector genes at more than half of known IBD loci, including MAML2, PSEN2 and ZMIZ1 in myeloid cells, implicating reduced Notch signalling in intestinal immune dysfunction. We also identify Wnt-regulated genes, including MYC, in epithelial stem and progenitor cells, suggesting that impaired renewal contributes to barrier breakdown. Our results provide a mechanistic map that links genetic risk to specific genes and cell types in IBD, and a generalized framework for interpretation of GWAS loci using single-cell eQTL mapping of disease-relevant tissues in complex diseases. Single-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-localize with genome-wide association study loci than those identified at the tissue level.",
            "content": "Patient recruitment and single-cell sequencing\nThis study was approved by the National Health Service (NHS) Research Ethics Committee (Cambridge South, REC ID 17/EE/0338). Written informed consent was given by all participants.\n296 individuals withou... [30265 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10627-z?error=cookies_not_supported&code=1b70061f-a47e-4feb-8ba1-e7d08f960b58",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10627-z/MediaObjects/41586_2026_10627_Fig1_HTML.png",
            "publishedAt": "2026-06-03T21:09:05Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "8e83e4a0f0d96c55ef4ee4696811a9db",
            "title": "Autodesk signs strategic collaboration agreement with Amazon Web Services",
            "description": "/PRNewswire/ -- Autodesk, Inc. (NASDAQ: ADSK), a global leader in design and make technology, today announced it has signed a strategic collaboration agreement...",
            "content": "Fusion products will be available via AWS Marketplace\nSAN FRANCISCO, June 3, 2026 /PRNewswire/ -- Autodesk, Inc. (NASDAQ: ADSK), a global leader in design and make technology, today announced it has signed a strategic collaboration agreement (SCA) wi... [3584 chars]",
            "url": "https://www.prnewswire.com/news-releases/autodesk-signs-strategic-collaboration-agreement-with-amazon-web-services-302790696.html",
            "image": "https://mmx.prnewswire.com/media/MS980141/Autodesk_Black_Logo.jpg?id=OA2657242&p=facebook",
            "publishedAt": "2026-06-03T21:00:00Z",
            "lang": "en",
            "source": {
                "id": "4e4307a07d2ce1e31acaf932954d3dd9",
                "name": "PR Newswire",
                "url": "https://www.prnewswire.com"
            }
        },
        {
            "id": "4310965f8cd346d4c0b8139b60556c65",
            "title": "Intuit CFO Sandeep Aujla to Present at the Nasdaq Investor Conference",
            "description": "MOUNTAIN VIEW, Calif.--(BUSINESS WIRE)--\nIntuit Inc. (Nasdaq: INTU), the global financial technology platform that makes Intuit TurboTax,…...",
            "content": "MOUNTAIN VIEW, Calif.--(BUSINESS WIRE)-- Intuit Inc. (Nasdaq: INTU), the global financial technology platform that makes Intuit TurboTax, Credit Karma, QuickBooks, Mailchimp, and Intuit Enterprise Suite, announced today that Sandeep Aujla, Intuit's c... [1197 chars]",
            "url": "https://investors.intuit.com/news-events/press-releases/detail/1314/intuit-cfo-sandeep-aujla-to-present-at-the-nasdaq-investor-conference",
            "image": "https://investors.intuit.com/_assets/_6a9ee074199c0a511699c988d19108db/intuit/db/939/7881/social_image.jpg",
            "publishedAt": "2026-06-03T20:59:54Z",
            "lang": "en",
            "source": {
                "id": "38ff811db3ba5de5fba07b64994a6bcd",
                "name": "Intuit",
                "url": "https://investors.intuit.com"
            }
        }
    ]
}