Pakistan Health News API

{
    "totalArticles": 63684,
    "articles": [
        {
            "id": "d85b7913285c5aa9492b0e0e229b61b5",
            "title": "Sindh monkeypox cases rise as Karachi reports second case",
            "description": "Sindh has recorded 14 monkeypox cases this year, including two in Karachi and 12 in Khairpur, with five deaths reported.",
            "content": "KARACHI: Sindh has reported 14 monkeypox infections so far this year, including 12 cases in Khairpur and two in Karachi, while five deaths have also been recorded, according to details shared in the report. The increase in cases has raised concern am... [2217 chars]",
            "url": "https://www.pakistantoday.com.pk/2026/04/10/monkeypox-cases-rise-in-sindh-as-karachi-reports-second-infection",
            "image": "https://i.tribune.com.pk/media/images/mpox1727109002-0/mpox1727109002-0.jpg",
            "publishedAt": "2026-04-10T06:19:05Z",
            "lang": "en",
            "source": {
                "id": "42f01186ca43680b240acb0cb5600463",
                "name": "Pakistan Today",
                "url": "https://www.pakistantoday.com.pk"
            }
        },
        {
            "id": "b4be429424f0df5e03c3d6908bbeb43f",
            "title": "Pakistan's current response to TB insufficient as cases continue to rise: Report",
            "description": "Islamabad, April 9 (SocialNews.XYZ) Tuberculosis (TB) remains one of the deadliest diseases in Pakistan as it claims tens of thousands of lives each year. More than 1,800 new cases of TB being reported daily and... - Social News XYZ",
            "content": "Islamabad, April 9 (SocialNews.XYZ) Tuberculosis (TB) remains one of the deadliest diseases in Pakistan as it claims tens of thousands of lives each year. More than 1,800 new cases of TB being reported daily and approximately 140 casualties each day ... [2427 chars]",
            "url": "https://www.socialnews.xyz/2026/04/09/pakistans-current-response-to-tb-insufficient-as-cases-continue-to-rise-report/",
            "image": "https://i0.wp.com/www.socialnews.xyz/wp-content/uploads/2026/04/09/202604093741065.jpg?fit=1379%2C1035&quality=80&zoom=1&ssl=1?v=1775745723",
            "publishedAt": "2026-04-10T01:50:25Z",
            "lang": "en",
            "source": {
                "id": "566028ed87d2760f4c69face25174110",
                "name": "Social News XYZ",
                "url": "https://www.socialnews.xyz"
            }
        },
        {
            "id": "2cedb400617e6e4520660e30cdd9b5f0",
            "title": "A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia",
            "description": "Microglia engulf dying neurons through efferocytosis, a critical function in both development and disease. How microglia process the engulfed neuronal material—especially lipids—remains poorly understood, despite its central role in neurodegeneration. Thus, we developed HuZIBRA, a scalable in vivo xenotransplantation model in which human iPSC-derived microglia-like cells (iMGLs) are introduced into the developing zebrafish brain (zf-hiMG), a system characterized by high levels of neuronal cell death and amenable to precise genetic and pharmacological manipulation. We show that human microglia-like cells recognize and engulf apoptotic zebrafish neurons, indicating conserved efferocytic mechanisms. In these cells, engulfed neuronal material accumulates into a distinct, lipid-rich intracellular compartment, the gastrosome, which we also observed in iMGLs placed in a human brain-like environment. The size of the human gastrosome dynamically reflects neuronal cell death levels and is regulated by key genes, including TREM2 and SLC37A2. Pharmacological inhibition of the cholesterol transporter NPC1 induces gastrosome expansion and lipid accumulation, recapitulating pathological features of Niemann-Pick disease type C. Thus, HuZIBRA provides a powerful in vivo platform to uncover cell-autonomous adaptive responses of human microglia to apoptotic and metabolic stress, with the gastrosome emerging as a key integrator of neuronal debris processing and disease-relevant lipid metabolism. Establishment of HuZIBRA, a xenotransplantation model where human iPSC-derived microglia engulf endogenous zebrafish dying neurons, forming a lipid-rich gastrosome regulated by TREM2, SLC37A2 and NPC1, linking neuronal debris processing to disease-relevant lipid metabolism.",
            "content": "Ashwell, K. Microglia and cell death in the developing mouse cerebellum. Dev. Brain Res. 55, 219–230 (1990).\nUeno, M. et al. Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 16, 543–551 (20... [10640 chars]",
            "url": "https://www.nature.com/articles/s42003-026-09948-6?error=cookies_not_supported&code=6a9c83a3-6eec-4535-a4f4-fd522cc0be80",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-04-09T19:07:30Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        }
    ]
}