Pakistan Health News API

{
    "totalArticles": 63440,
    "articles": [
        {
            "id": "549a125bedb240a2b7d1770284a15f9d",
            "title": "Single-cell spatiotemporal dissection of the human maternal-fetal interface",
            "description": "The human maternal–fetal interface is characterized by mosaic intermingling of maternal and fetal cells1. Yet the underlying cellular, molecular and spatial programmes remain incompletely defined. Here we generate a comprehensive atlas of the human maternal–fetal interface across normal pregnancies from early gestation to term by integrating large-scale paired single-nucleus transcriptomic and chromatin accessibility profiling with submicrometre-resolution spatial transcriptomics and CODEX multiplex protein imaging2, substantially boosting the spatiotemporal resolution of prior research3. This framework delineates common and transient cell types, states and spatial niches across the fetal and maternal compartments, reconstructs transcriptional programmes that guide cytotrophoblast and decidual stromal cell differentiation, and resolves recurrent architecture structural units that build this interface. We identify previously unrecognized arterial endothelial state transitions during cytotrophoblast-mediated spiral artery remodelling and develop a machine learning model that predicts cytotrophoblast invasiveness from transcriptomic signatures. We further discover a decidual stromal cell subtype that suppresses cytotrophoblast invasion via endocannabinoid signalling at the human maternal–fetal interface. By integrating the atlas with genome-wide association data, we pinpoint maternal and fetal cells that are most vulnerable to pre-eclampsia, preterm birth or miscarriage. This resource provides a comprehensive spatially resolved single-cell multiomic reference of the human placenta and decidua and offers a framework for decoding their normal and disordered development. A single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.",
            "content": "Tissue acquisition and processing for joint single-nucleus multiome profiling and spatial transcriptomics\nSnap-frozen decidual and basal plate samples were obtained from the existing placenta tissue banks at Stanford University and University of Cali... [25043 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10316-x?error=cookies_not_supported&code=68bc4657-7215-47a9-b76a-d771fa1aa460",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10316-x/MediaObjects/41586_2026_10316_Fig1_HTML.png",
            "publishedAt": "2026-04-08T21:57:35Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "9c194d85be8a0136e99ee94191d894ce",
            "title": "Breastfeeding patterns in India differ between slum and non-slum neighborhoods",
            "description": "A new study from the University of Toronto shows that where a mother lives in an Indian city – in a slum or a non‑slum neighborhood – is linked to how she breastfeeds her baby.",
            "content": "A new study from the University of Toronto shows that where a mother lives in an Indian city – in a slum or a non‑slum neighborhood – is linked to how she breastfeeds her baby.\nBreastfeeding within one hour of birth helps newborns fight infection and... [3827 chars]",
            "url": "https://www.news-medical.net/news/20260408/Breastfeeding-patterns-in-India-differ-between-slum-and-non-slum-neighborhoods.aspx",
            "image": "https://www.news-medical.net/image-handler/picture/2014/7/147309906-620x480.jpg",
            "publishedAt": "2026-04-08T19:31:00Z",
            "lang": "en",
            "source": {
                "id": "f2ca7a45d20357cb42858868cb4a4946",
                "name": "News-Medical",
                "url": "https://www.news-medical.net"
            }
        },
        {
            "id": "0a23ae9341a6a88d40cfdeabeb0d4f2e",
            "title": "Neuroblastoma Tumor Growth in Mice Suppressed by Blocking Enzyme to Inhibit mTOR Signaling",
            "description": "Study in cells and in mice identifies the nNOS–mTOR axis as a promising therapeutic target in neuroblastoma.",
            "content": "Neuroblastoma is the most common tumor among children under a year of age, and while in its gentlest form neuroblastoma can regress on its own, it can also take an aggressive form, with high-risk neuroblastoma carrying a five-year survival rate of ab... [10237 chars]",
            "url": "https://www.genengnews.com/topics/cancer/neuroblastoma-tumor-growth-in-mice-suppressed-by-blocking-enzyme-to-inhibit-mtor-signaling/",
            "image": "https://www.genengnews.com/wp-content/uploads/2018/08/May28_2014_346419_BabyInHospital_PlacentaGirlBabies2341011081.jpg",
            "publishedAt": "2026-04-08T19:18:55Z",
            "lang": "en",
            "source": {
                "id": "44d4211fca4dbb83c12712451a910c36",
                "name": "Genetic Engineering and Biotechnology News",
                "url": "https://www.genengnews.com"
            }
        }
    ]
}