Pakistan Health News API

{
    "totalArticles": 63954,
    "articles": [
        {
            "id": "9f29848191af8bb58f3111fbfd06ae02",
            "title": "Identification and validation of prognostic genes associated with integrative stress response in lung adenocarcinoma and construction of the risk models",
            "description": "​Integrated stress response (ISR) genes are implicated in lung adenocarcinoma (LUAD) prognosis, but their clinical utility remains unexplored. This study aims to identify ISR-related prognostic genes and construct a risk model for LUAD survival prediction.​ LUAD transcriptomic and clinical data were retrieved from public databases. ISR-related genes (ISR-RGs) were screened via differential expression and regression analysis. A risk model and a nomogram integrating clinical indicators were built and validated. Functional enrichment, immune cell infiltration, and RT-qPCR in clinical samples were performed.​​​ Five prognostic genes (AGER, GPX3, CCNA2, KCNK3, and CHEK1) were identified. High-risk patients exhibited poorer survival. The nomogram was able to forecast the survival of LUAD well. Genes were functionally linked to cell cycle and DNA replication and correlated with immune cells (e.g., CCNA2 positively with CD4⁺ T cells [cor = 0.52]; CHEK1 negatively with memory B cells [cor = − 0.40]). RT-qPCR confirmed dysregulation: AGER, GPX3, and KCNK3 downregulated and CHEK1 and CCNA2 upregulated versus controls. The five prognostic genes pertinent to both LUAD and ISR were identified, and a risk model was constructed for the good prediction of LUAD survival, which offered a fresh outlook for alleviating the poor prognosis of LUAD.",
            "content": "Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229–263 (2024).\nZhang, W. et al. Identification of cuproptosis and immune-related gene prog... [16151 chars]",
            "url": "https://www.nature.com/articles/s41598-026-40547-x?error=server_error",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-02-27T21:22:30Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "0ade505341062d53f4f90581ae0ad655",
            "title": "Over 40% of health care workers had insomnia during, after COVID pandemic peak",
            "description": "Both geographic location and work setting are tied to insomnia risk.",
            "content": "The European Medicines Agency (EMA) today said it’s recommending marketing authorization for mCombriax, Moderna’s combined mRNA vaccine for protecting older adults against COVID-19 and flu.\nThe recommendation was made by the EMA’s Committee for Medic... [1317 chars]",
            "url": "https://www.cidrap.umn.edu/covid-19/over-40-health-care-workers-had-insomnia-during-after-covid-pandemic-peak",
            "image": "https://www.cidrap.umn.edu/themes/custom/cidrap_theme/images/cidrap-og-image.jpg",
            "publishedAt": "2026-02-27T18:39:00Z",
            "lang": "en",
            "source": {
                "id": "29fcba365dad1c5ca0a8efcd57b4bc8e",
                "name": "CIDRAP",
                "url": "https://www.cidrap.umn.edu"
            }
        },
        {
            "id": "d40070af40b3fff2f030d1d513c2e140",
            "title": "Young adult astrocytoma survivor puts trust in doctors during treatment",
            "description": "After she received a brain tumor diagnosis days before her 32nd birthday, Hannah Kahn came to MD Anderson for treatment. She shares how her care team made her feel comfortable and how she’s connected with other cancer patients.",
            "content": "Two months into her marriage and just two days before her 32nd birthday, Hannah Kahn learned that she had a brain tumor.\n“I’ve run four marathons and 17 half-marathons,” says Hannah. “I’m extremely active, and I never get sick. So, finding out I had ... [3543 chars]",
            "url": "https://www.mdanderson.org/cancerwise/young-adult-astrocytoma-survivor-puts-trust-in-doctors-during-brain-tumor-treatment.h00-159852978.html",
            "image": "https://www.mdanderson.org/cancerwise/2026/02/young-adult-astrocytoma-survivor-puts-trust-in-doctors-during-brain-tumor-treatment/jcr:content/blog/adaptiveimage.resize.702.404.jpg",
            "publishedAt": "2026-02-27T15:08:34Z",
            "lang": "en",
            "source": {
                "id": "bda0b2e301789513cff655b7c2190fa8",
                "name": "MD Anderson Cancer Center",
                "url": "https://www.mdanderson.org"
            }
        }
    ]
}