Pakistan Health News API

{
    "totalArticles": 63626,
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        {
            "id": "2cedb400617e6e4520660e30cdd9b5f0",
            "title": "A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia",
            "description": "Microglia engulf dying neurons through efferocytosis, a critical function in both development and disease. How microglia process the engulfed neuronal material—especially lipids—remains poorly understood, despite its central role in neurodegeneration. Thus, we developed HuZIBRA, a scalable in vivo xenotransplantation model in which human iPSC-derived microglia-like cells (iMGLs) are introduced into the developing zebrafish brain (zf-hiMG), a system characterized by high levels of neuronal cell death and amenable to precise genetic and pharmacological manipulation. We show that human microglia-like cells recognize and engulf apoptotic zebrafish neurons, indicating conserved efferocytic mechanisms. In these cells, engulfed neuronal material accumulates into a distinct, lipid-rich intracellular compartment, the gastrosome, which we also observed in iMGLs placed in a human brain-like environment. The size of the human gastrosome dynamically reflects neuronal cell death levels and is regulated by key genes, including TREM2 and SLC37A2. Pharmacological inhibition of the cholesterol transporter NPC1 induces gastrosome expansion and lipid accumulation, recapitulating pathological features of Niemann-Pick disease type C. Thus, HuZIBRA provides a powerful in vivo platform to uncover cell-autonomous adaptive responses of human microglia to apoptotic and metabolic stress, with the gastrosome emerging as a key integrator of neuronal debris processing and disease-relevant lipid metabolism. Establishment of HuZIBRA, a xenotransplantation model where human iPSC-derived microglia engulf endogenous zebrafish dying neurons, forming a lipid-rich gastrosome regulated by TREM2, SLC37A2 and NPC1, linking neuronal debris processing to disease-relevant lipid metabolism.",
            "content": "Ashwell, K. Microglia and cell death in the developing mouse cerebellum. Dev. Brain Res. 55, 219–230 (1990).\nUeno, M. et al. Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 16, 543–551 (20... [10640 chars]",
            "url": "https://www.nature.com/articles/s42003-026-09948-6?error=cookies_not_supported&code=6a9c83a3-6eec-4535-a4f4-fd522cc0be80",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-04-09T19:07:30Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "a824c875c28b822e27c1217e15f2e19b",
            "title": "CAR-T therapy could treat severe autoimmune diseases, shows study",
            "description": "Earlier intervention in severe autoimmune diseases may help prevent complications following previous ineffective treatments.",
            "content": "For the first time, a CD19 CAR-T cell therapy has shown high efficiency in managing three different severe autoimmune diseases.\nThe study, conducted on one female patient, demonstrated achievement of remission, with no further treatment required a ye... [1753 chars]",
            "url": "https://www.europeanpharmaceuticalreview.com/car-t-therapy-could-treat-severe-autoimmune-diseases-shows-study/2135165.article",
            "image": "https://d3t5t78xsxj5vn.cloudfront.net/Pictures/1024x536/4/3/6/20436_shutterstock_2460506615_162059.jpg",
            "publishedAt": "2026-04-09T16:25:28Z",
            "lang": "en",
            "source": {
                "id": "0c68ea905b6e9deae1735956ac47fc0f",
                "name": "European Pharmaceutical Review",
                "url": "https://www.europeanpharmaceuticalreview.com"
            }
        },
        {
            "id": "aeaa2ba460075533199341feebd9da9b",
            "title": "One woman, three autoimmune diseases: CAR-T therapy vanquishes ultra-rare disease trio",
            "description": "Fourteen months after treatment with engineered immune cells, the recipient has no symptoms and doesn’t need to take medication.",
            "content": "A woman with an ultra-rare combination of three autoimmune diseases has had no symptoms since receiving a single dose of engineered immune cells, doctors in Germany report today1. She had previously received nine other types of treatment without gett... [2741 chars]",
            "url": "https://www.nature.com/articles/d41586-026-01108-4?error=cookies_not_supported&code=de204364-d4e8-4b9a-bfd2-510204a71c7c",
            "image": "https://media.nature.com/lw1200/magazine-assets/d41586-026-01108-4/d41586-026-01108-4_52262908.jpg",
            "publishedAt": "2026-04-09T15:25:34Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        }
    ]
}