Pakistan Health News API

{
    "totalArticles": 63942,
    "articles": [
        {
            "id": "d878f1f1331935d06b6c36c787b3eac8",
            "title": "Distinct genomic trajectory among invasive Salmonella Typhimurium ST313 infections",
            "description": "Invasive non-typhoidal Salmonella (iNTS) disease, primarily manifesting as bloodstream infections and dominated by Salmonella Typhimurium sequence type 313 (ST313), represents a major global health challenge, particularly in sub-Saharan Africa. However, the transmission landscape and evolutionary driver of ST313 remain incompletely understood. Here, we compile the global dataset to date, comprising 11,361 human-derived iNTS genomes and 3115 ST313 genomes from diverse sources, enabling identification of a highly antimicrobial-resistant sublineage 2.4 and an emerging lineage 4. Phylogenomic analyses reveal patterns consistent with intercontinental dissemination of ST313, which may be associated with modernized human biomass movement. Sublineage 2.4, an antimicrobial-resistant offshoot that displaced lineage 1, harbors extended-spectrum β-lactamase genes, including blaOXA-1, blaCTX-M-15, often linked to mobilome, suggesting a potential trend of increasing resistance within lineage 2. Furthermore, mobilome-driven alterations in antimicrobial-resistant gene carriage coincide with the post-2006 decline of lineage 1 in Africa. Additional genetic changes may enhance invasiveness and competitive fitness , including enrichment of pseudogenes and positively selected functional genes, which may have facilitated replacement by newly identified ST313 clone. Together, Our findings highlight lineage-specific selection pressures shaped by anthropogenic factors, such as antimicrobial use and stewardship, that modulate ST313 evolution and underscore the need for enhanced surveillance. Invasive Salmonella Typhimurium ST313 poses a threat to human health. This genomic study uncovers the potential global transmission and origins of diverse branches, highlighting the pivotal role of antimicrobial resistance in the evolution of S. Typhimurium ST313.",
            "content": "Wang, H., Tang, L., Zhou, H., Xie, P. & Yue, M. Illuminating the genomic frontier of invasive non-typhoidal Salmonella infections. Clin. Transl. Med 15, e70526 (2025).\nWang, H. & Yue, M. W. H. O. Pandemic agreement: the need for scientific implementa... [11966 chars]",
            "url": "https://www.nature.com/articles/s41467-026-70196-7?error=cookies_not_supported&code=3bfc73d1-b30c-4530-88f4-7cc525da772d",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-03-09T16:41:15Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "903f7227841322970c440b518059fcf7",
            "title": "Recreational Adderall Causes Worrisome Spikes in BP, Heart Rate",
            "description": "The study should be the first of many helping to understand the negative CV effects of the drug in an illicit setting, say authors.",
            "content": "Unprescribed use of amphetamine-dextroamphetamine salts (Adderall) can cause sizeable increases in blood pressure, heart rate, and sympathetic activation after only a single pill, according to new data.\nAmong more than two dozen healthy individuals w... [4258 chars]",
            "url": "https://www.tctmd.com/news/recreational-adderall-causes-worrisome-spikes-bp-heart-rate",
            "image": "https://d14d5nk8lue86f.cloudfront.net/s3fs-public/2026-03/Recreational%20Adderall%20Causes%20Worrisome%20Spikes%20in%20BP%2C%20Heart%20Rate.jpg",
            "publishedAt": "2026-03-09T16:28:33Z",
            "lang": "en",
            "source": {
                "id": "6f1cf3918c9974e771cdda266d6941f0",
                "name": "TCTMD.com",
                "url": "https://www.tctmd.com"
            }
        },
        {
            "id": "7bd21b922d707b15ea178a81816210f4",
            "title": "Lassa fever is going undiagnosed in West Africa, risking global spread",
            "description": "A new Lancet study says undiagnosed infections of the Ebola-like disease are endangering patients in West Africa and beyond.",
            "content": "Lassa fever kills thousands of people every year in West Africa, but many of those infections go undiagnosed until it’s too late.\nWith the Ebola-like haemorrhagic disease now emerging in hospitals from Iowa to Johannesburg and Beijing, it’s a problem... [4445 chars]",
            "url": "https://www.gavi.org/vaccineswork/lassa-fever-going-undiagnosed-west-africa-risking-global-spread",
            "image": "https://www.gavi.org/sites/default/files/vaccineswork/2026/header/national-institute-of-allergy-and-infectious-diseases-WBqg25skfiw-unsplash_h1.jpg",
            "publishedAt": "2026-03-09T15:26:14Z",
            "lang": "en",
            "source": {
                "id": "5f776fe7a8acab845ca9a339d4437a16",
                "name": "Gavi, the Vaccine Alliance",
                "url": "https://www.gavi.org"
            }
        }
    ]
}