Pakistan Health News API

{
    "totalArticles": 61236,
    "articles": [
        {
            "id": "238cc146ccbf04710779faff2d5a8285",
            "title": "Molecular docking and dynamic simulation of marine natural products from soft coral-derived microbes against SARS-CoV-2 main protease and spike protein",
            "description": "Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Two key therapeutic target proteins of SARS-CoV-2, the Spike (S) protein and the main protease (Mpro), facilitate the entry of virus and its replication inside the host cell, respectively. Notably, several pointmutations in the receptor-binding domain (RBD) of the S-protein have led to the origin of different SARS-CoV-2 Variants of Concern (VOCs) including Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2), Gamma (P.1), and Omicron (B.1.1.529). The low efficacy of currently available antiviral drugs against these VOCs highlights the need for screening and discovery of novel natural compounds against COVID-19. This study performed molecular docking of marine natural products from soft coral-derived microbes against the Mpro and the RBD of the S-protein from wild type (WT) and five VOCs. Many of the test compounds [e.g., Cottoquinazoline B and D (CQB/D), Tetraorcinol A (TOA), Versicoloritide A and C (VCA/C), Fumiquinazoline K, and Pencillanthranin A) showed stronger binding affinities compared to control antiviral drugs (nelfinavir and remdesivir) and formed favorable interactions with both Mpro and the RBD of S-protein. ADMET analysis revealed that most of the best-docked compounds obey Lipinski rule of five. Molecular dynamics (MD) simulation (200 ns) analysis further revealed stable binding conformations of the top docked complexes of (1) CQB with Mpro, (2) CQB with the RBD of WT S-protein, (3) TOA with the RBD of S-protein from beta variant (4) TOA with the RBD of S-protein from Omicron variant, (5) TOA with the RBD of S-protein from Delta variant, (6) TOA with the RBD of S-protein from Gamma variant, and (7) VCA with the RBD of alpha variant. However, future in vitro and in vivo studies are still required to validate efficacy of these compounds.",
            "content": "Isa, M. A. et al. In Silico molecular Docking and molecular dynamic simulation of potential inhibitors of 3 C-like main proteinase (3CLpro) from severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) using selected African medicinal plants. Adv... [10169 chars]",
            "url": "https://www.nature.com/articles/s41598-026-37446-6?error=cookies_not_supported&code=69fb2bfe-ed21-4c15-bccd-1c939c608f1b",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-02-11T03:41:22Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "b9598c6d510d3e17ffad308ff9a83da8",
            "title": "Ho Chi Minh City to screen all arrivals for Nipah virus",
            "description": "Ho Chi Minh City will step up border surveillance, introduce remote temperature screening for all arrivals and prepare hospital resources to prevent the spread of the Nipah virus.",
            "content": "Under a newly issued plan by the municipal People’s Committee, the city will strengthen disease monitoring and prevention at border gates, with quarantine measures applied comprehensively while maintaining smooth entry and exit procedures.\nAuthoritie... [4808 chars]",
            "url": "https://dtinews.dantri.com.vn/vietnam-today/ho-chi-minh-city-to-screen-all-arrivals-for-nipah-virus-20260211070622056.htm",
            "image": "https://icdn.dantri.com.vn/2026/02/10/tphcm-do-than-nhiet-tu-xa-tat-ca-khach-nhap-canh-de-phong-virus-nipah-1-edited-1770728513980.jpg",
            "publishedAt": "2026-02-11T00:06:00Z",
            "lang": "en",
            "source": {
                "id": "60afc5e6c80d57b4c884c5bda2ed4951",
                "name": "DTiNews",
                "url": "https://dtinews.dantri.com.vn"
            }
        },
        {
            "id": "89c4532f0688fb67c82d97dd5a7c20f2",
            "title": "Exercise can be ‘frontline treatment’ for mild depression, researchers say",
            "description": "Biggest improvements seen in young adults and new mothers, with group activities of most benefit",
            "content": "Aerobic exercise such as running, swimming or dancing can be considered a frontline treatment for mild depression and anxiety, according to research that suggests working out with others brings the most benefits.\nScientists analysed published reviews... [3255 chars]",
            "url": "https://www.theguardian.com/society/2026/feb/10/aerobic-exercise-frontline-treatment-mild-depression-study",
            "image": "https://i.guim.co.uk/img/media/009beeed8b1642cdc608585dc67859003ced5660/142_0_4680_3744/master/4680.jpg?width=1200&height=630&quality=85&auto=format&fit=crop&precrop=40:21,offset-x50,offset-y0&overlay-align=bottom%2Cleft&overlay-width=100p&overlay-base64=L2ltZy9zdGF0aWMvb3ZlcmxheXMvdGctZGVmYXVsdC5wbmc&enable=upscale&s=411492040e5db23a7ec76e6d025021aa",
            "publishedAt": "2026-02-10T23:30:00Z",
            "lang": "en",
            "source": {
                "id": "558a003a7a0164e924408edec7e99f99",
                "name": "The Guardian",
                "url": "https://www.theguardian.com"
            }
        }
    ]
}