Botswana Science News API

{
    "totalArticles": 1559,
    "articles": [
        {
            "id": "a0a371f5786547e4364d2e77bdd432a5",
            "title": "The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication",
            "description": "Castration-resistant prostate cancer (CRPC) is a fatal malignancy often associated with alterations in cell cycle regulation, particularly within the Cyclin/CDK/RB axis. Despite ongoing clinical trials assessing CDK4/6 inhibitors in prostate cancer, clinical evidence remains limited. Although the androgen receptor (AR) inhibitor enzalutamide (ENZ) initially demonstrates therapeutic efficacy, resistance develops over time, and monotherapy offers limited antitumor benefits, highlighting the need for effective combination therapies. In this study, pharmacological profiling, genetic dependency analysis, RNA sequencing, and functional validation were conducted across various in vitro and in vivo preclinical CRPC models. The combination of ENZ and the CDK4/6 inhibitor dalpiciclib (DAL) exhibited potent antitumor activity in CRPC cell lines, a cell-derived xenograft (CDX) model, and a lymphatic metastatic model. Moreover, ENZ plus DAL inhibited cell cycle progression, migration, and DNA replication, while promoting apoptosis in CRPC cells. Mechanistically, ENZ blocked AR-mediated transcriptional activation of MCM4, a critical component of the DNA helicase complex, thereby enhancing the effect of CDK4/6 inhibition on DNA replication and inducing a pronounced synergistic antitumor response. These results suggest that the ENZ-DAL combination is a promising therapeutic approach that warrants further clinical evaluation in CRPC patients.",
            "content": "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original... [625 chars]",
            "url": "https://www.nature.com/articles/s41419-026-08959-9?error=cookies_not_supported&code=7a962564-bb77-4fce-919c-7226f6fd6ae6",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-06-05T04:48:43Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "aadc547e4e0ea1e122792417654caa0d",
            "title": "New Cloud-Detecting Method Will Help Astronomers Characterize Exoplanets",
            "description": "Astronomers have developed a technique that allows them to detect cloud cycles on distant exoplanets. Using data from the James Webb Sapce Telescope (JWST), the astronomers found that mornings and evenings on the gas giant WASP-94A b have extremely different weather patterns: mornings are riddled with sand clouds, while the skies are clear in the early evenings. By isolating the clouds, researchers can more accurately measure a planet’s atmosphere and provide a clearer picture of the planet’s composition. WASP-94A b, for example, has much less oxygen and carbon than astronomers perviously calculated, making its atmosphere much more like Jupiter than they had originally thought.",
            "content": "The current exoplanet census stands at 6,291 confirmed candidates across 4,709 systems, with tens of thousands awaiting confirmation. With so many planets available for study and improvements in both instruments and methods, the process is transition... [6407 chars]",
            "url": "https://www.universetoday.com/articles/new-cloud-detecting-method-will-help-astronomers-characterize-exoplanets",
            "image": "https://www.universetoday.com/article_images/WASP94Ab_20260602_170536.jpg",
            "publishedAt": "2026-06-04T22:54:00Z",
            "lang": "en",
            "source": {
                "id": "e209c18934dfc136fe2651208d3d9a69",
                "name": "Universe Today",
                "url": "https://www.universetoday.com"
            }
        },
        {
            "id": "3c82c594e3bb8b711d72e87370ad3014",
            "title": "Hidden actin web lets skin cells share mechanical force over long distances",
            "description": "Scientists at Université de Montréal's Institute for Research in Immunology and Cancer (IRIC) have identified a dynamic structure that forms a network on the surface of epithelial cells. Led by Gregory Emery, director of IRIC's vesicular trafficking and cell signaling research unit, and Ph.D. students Claire Baudouin and Léa Marpeaux, the research is published in the Journal of Cell Science. It shows that, in certain skin cells, actin fibers can connect with neighboring cells to form a shared network on the surface of the tissue.",
            "content": "Scientists at Université de Montréal's Institute for Research in Immunology and Cancer (IRIC) have identified a dynamic structure that forms a network on the surface of epithelial cells. Led by Gregory Emery, director of IRIC's vesicular trafficking ... [1617 chars]",
            "url": "https://medicalxpress.com/news/2026-06-hidden-actin-web-skin-cells.html",
            "image": "https://scx2.b-cdn.net/gfx/news/hires/2026/epithelial-cells.jpg",
            "publishedAt": "2026-06-04T18:40:03Z",
            "lang": "en",
            "source": {
                "id": "fc12437cc984742bf9a97820262ab48a",
                "name": "Medical Xpress",
                "url": "https://medicalxpress.com"
            }
        }
    ]
}