United Kingdom Health News API

{
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        {
            "id": "5e7edb1701094acf1532597fb743c3ef",
            "title": "Tumour promotion through the lens of evolution",
            "description": "Almost all tumours carry one or more cancer driver mutations, which are essential for cell transformation. However, recent advances in cancer genomics have demonstrated that normal human tissues contain millions of cells carrying known driver mutations, while preserving homeostasis. Most of these mutated cells will never transform into tumours. Moreover, studies of known or suspected human carcinogens have shown that the majority are not mutagens. These observations suggest that exogenous carcinogenic exposures might increase cancer risk by modifying selective constraints, promoting the expansion of pre-existing clones carrying specific oncogenic mutations. In this Review, we propose a synthesis between ideas put forward almost a century ago based on seminal experiments on carcinogen-induced tumours in mice, observations made by cancer epidemiologists over several decades, and the recent revelation that normal human tissues are a patchwork of mutant clones. The repeated interplay between variation and selection—the first principles of Darwinian evolution—underlies the clonal selection leading to tumorigenesis. A deeper understanding of these processes can enhance prospects for cancer prevention by eliminating or mitigating the effects of environmental or endogenous tumour promoters. This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous factors to expand tumorigenic clones.",
            "content": "Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23–28 (1976).\nHanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011).\nBissell, M. J. & Hines, W. C. Why don’t we get more cancer? A p... [32878 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10386-x?error=cookies_not_supported&code=afcaa8cb-cad6-4b9a-b074-346a50eafd26",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10386-x/MediaObjects/41586_2026_10386_Fig1_HTML.png",
            "publishedAt": "2026-04-15T19:29:52Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "eb05d75332ce024b55e409c30815f9df",
            "title": "Death of Surrey man prompts skin cancer healthcare concerns",
            "description": "A coroner says the death of Gary Starbuck, 81, highlights a gap in care for high risk patients.",
            "content": "Some private skin cancer patients could receive \"inferior care\" compared to those in the NHS, a coroner has warned after a man's death.\nGary Starbuck, 81, from Cranleigh in Surrey, died in August 2021 after being treated for skin cancer, which later ... [1014 chars]",
            "url": "https://www.bbc.co.uk/news/articles/ckgee8exepzo",
            "image": "https://ichef.bbci.co.uk/ace/branded_news/1200/cpsprodpb/a730/live/828aa5b0-38d5-11f1-897a-bdd15f22bdb0.jpg",
            "publishedAt": "2026-04-15T15:35:19Z",
            "lang": "en",
            "source": {
                "id": "da05009467a13bbcc84557ea09d86db3",
                "name": "BBC",
                "url": "https://www.bbc.co.uk"
            }
        },
        {
            "id": "302fac3ebf623040873d52a7c25a9ec7",
            "title": "Vaping left black holes in my teeth, says Swansea ex dental nurse",
            "description": "Stacey Gardiner, 41, wants better warnings about how excessive vaping can damage your teeth.",
            "content": "A former dental nurse whose £120-a-month vape addiction left her with two \"black\" front teeth is warning about the dangers.\nStacey Gardiner, 41, from Swansea, started vaping in 2017 and got hooked, sometimes using a standard 600-puff vape in just one... [2377 chars]",
            "url": "https://www.bbc.co.uk/news/articles/c5y8845jyqko",
            "image": "https://ichef.bbci.co.uk/ace/branded_news/1200/cpsprodpb/fa22/live/f8cec1b0-38bd-11f1-883f-2b010a576163.jpg",
            "publishedAt": "2026-04-15T15:14:14Z",
            "lang": "en",
            "source": {
                "id": "da05009467a13bbcc84557ea09d86db3",
                "name": "BBC",
                "url": "https://www.bbc.co.uk"
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}