Israel Health News API

{
    "totalArticles": 19140,
    "articles": [
        {
            "id": "7f0607a56d91ee2394c8c8f74aa29933",
            "title": "Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding",
            "description": "Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ~40-50% of cases1,2. However, current therapies fail to target most such mutations because the mutant proteins typically lack defined drug-binding pockets, and restoring the endogenous function has proven challenging. Here, we programmed CRISPR-Cas12a2, an RNA-guided nuclease with trans-nucleolytic cleavage activities3,4, to selectively kill cancer cells by targeting cancer-specific transcripts. This approach limits cell growth by inducing trans shredding of chromatin, triggering DNA damage responses and cell death. Unlike existing methods, RNA-guided Cas12a2 senses cellular RNA signatures, enabling precise targeting of undruggable mutations. Transcript-activated chromatin shredding provides a new approach to precision disease treatments for undruggable targets.",
            "content": "Genetic mutations that drive cancer often occur in tumor suppressor proteins, including the p53 transcription factor which is altered in ~40-50% of cases1,2. However, current therapies fail to target most such mutations because the mutant proteins ty... [659 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10738-7?error=cookies_not_supported&code=5743d166-9cc8-44b5-9654-cf7343af749e",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-06-08T22:03:13Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "38fb33815be05cf4685c5a00fcad2d1d",
            "title": "Large Study Links GLP-1s to Lower Risk of Multiple Cancers",
            "description": "Patients taking the drugs for obesity had a 41% lower risk of related cancers",
            "content": "Patients taking GLP-1 receptor agonists for obesity had a 41% lower risk of obesity-related cancers as compared with patients treated with diet or exercise, a large propensity-matched cohort study showed.\nAfter 2 years of follow-up, the GLP-1 group h... [4591 chars]",
            "url": "https://www.medpagetoday.com/hematologyoncology/othercancers/121659",
            "image": "https://assets.medpagetoday.net/media/images/121xxx/121659.jpg",
            "publishedAt": "2026-06-08T19:56:12Z",
            "lang": "en",
            "source": {
                "id": "572d25e23e12ec1560e8ee1884a7057a",
                "name": "MedPage Today",
                "url": "https://www.medpagetoday.com"
            }
        },
        {
            "id": "bd16dd266bdc5edbf2b002a79a30d1af",
            "title": "מתקשה להיכנס להיריון? ייתכן שתגיעי לגיל המעבר מוקדם יותר",
            "description": "הקושי להיכנס להיריון והגיל שבו תגיעי לגיל המעבר אולי נראים כמו שני אירועים נפרדים, אבל מחקר חדש מגלה שהם עשויים להיות קשורים זה לזה. כל הפרטים",
            "content": "כשנשים פונות לטיפולי פוריות, רובן מתמקדות בשאלה אחת: האם יצליחו להיכנס להיריון. מחקר חדש מצביע על כך שהסיפור עשוי להיות רחב הרבה יותר. לפי המחקר, נשים שסבלו מאי־פוריות ראשונית, כלומר מצב שבו אישה מעולם לא הצליחה להיכנס להיריון למרות ניסיונות ממושכים,... [2578 chars]",
            "url": "https://www.atmag.co.il/%D7%9E%D7%94-%D7%94%D7%A7%D7%A9%D7%A8-%D7%91%D7%99%D7%9F-%D7%90%D7%99-%D7%A4%D7%95%D7%A8%D7%99%D7%95%D7%AA-%D7%95%D7%92%D7%99%D7%9C-%D7%94%D7%9E%D7%A2%D7%91%D7%A8/",
            "image": "https://medias.atmag.co.il/www/uploads/2026/06/medium-shot-woman-checking-pregnancy-test-1140x641.jpg",
            "publishedAt": "2026-06-08T14:17:42Z",
            "lang": "he",
            "source": {
                "id": "dd5bd25a7e1718ee50569cacea23a4ff",
                "name": "מגזין את",
                "url": "https://www.atmag.co.il"
            }
        }
    ]
}