Israel Health News API

{
    "totalArticles": 17368,
    "articles": [
        {
            "id": "c1167c532b48d4a05813de30fd0cfe80",
            "title": "Patient-derived prostate organoids identify MAOA as a disease severity-associated molecular marker in chronic pelvic pain syndrome",
            "description": "Chronic pelvic pain syndrome (CPPS) is a multifactorial condition with unclear pathophysiology and a lack of objective biomarkers for assessing disease activity. To investigate its molecular basis, we generated patient-derived prostate organoids from biopsy tissues of nine patients with CPPS, categorized as mild, moderate, or severe according to the NIH CP Symptom Index scores. The organoids were treated with Eviprostat or tadalafil, followed by transcriptomic profiling, quantitative RT-PCR validation, and immunohistochemical analysis of candidate genes. Among the differentially expressed genes, monoamine oxidase A (MAOA) and calbindin-D28K (CALB1) were consistently associateds with symptom severity. Expression of both genes decreased in organoids and prostate tissues as symptom severity increased, whereas serum MAOA levels were significantly elevated in patients with severe CPPS. These findings suggest that MAOA and CALB1 reflect molecular alterations linked to symptom intensity and may serve as potential biomarkers for CPPS. Furthermore, patient-derived prostate organoids offer a valuable experimental platform for elucidating disease mechanisms and evaluating therapeutic interventions in prostatitis-related disorders.",
            "content": "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original... [625 chars]",
            "url": "https://www.nature.com/articles/s41598-026-53351-4?error=cookies_not_supported&code=49141b66-c34b-4acc-8d65-4e8a977bd8b5",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-05-19T18:57:35Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "f346540c3c429fa1a45af94d8a5e3167",
            "title": "Routine test may reveal hidden stroke risk years before it happens",
            "description": "Routine ECG tests may help doctors detect hidden stroke risk up to 10 years before symptoms appear, using AI to analyze subtle heart signals.",
            "content": "A stroke risk calculation, done right, demands a lot. Blood pressure numbers, cholesterol levels, diabetes status, and smoking history are all fed into a scoring tool that most clinics never actually run on routine patients.\nWhat clinics do routinely... [5224 chars]",
            "url": "https://www.earth.com/news/routine-test-may-reveal-hidden-stroke-risk-years-before-it-happens/",
            "image": "https://cff2.earth.com/uploads/2026/05/19112838/stroke-risk-test.jpg",
            "publishedAt": "2026-05-19T18:33:45Z",
            "lang": "en",
            "source": {
                "id": "fca72a05020e12df547eedb79c870663",
                "name": "Earth.com",
                "url": "https://www.earth.com"
            }
        },
        {
            "id": "7592d044b3cdc991b92a1bd3e2fed000",
            "title": "Thirteen Spaniards isolated at Gómez Ulla with hantavirus can receive visitors",
            "description": "The only confirmed positive case continues to do well and is eager to begin a 'normal quarantine'. From Tuesday, the 13 in isolation may leave their single rooms wearing PPE and masks.",
            "content": "In Spain, Madrid's Gómez Ulla Hospital is working this Tuesday to ensure that the 13 people isolated after contact with hantavirus who have once again tested negative can receive \"staggered and safe\" visits this week, while the only confirmed positiv... [1867 chars]",
            "url": "https://www.euronews.com/health/2026/05/19/thirteen-spaniards-isolated-at-gomez-ulla-with-hantavirus-can-receive-visitors",
            "image": "https://images.euronews.com/articles/stories/09/76/45/49/1200x675_cmsv2_a81493e8-bf1b-5aff-932e-ec62343ed7d7-9764549.jpg",
            "publishedAt": "2026-05-19T16:25:41Z",
            "lang": "en",
            "source": {
                "id": "fe7887ab38dfaf6c0f8af3a124d38295",
                "name": "Euronews.com",
                "url": "https://www.euronews.com"
            }
        }
    ]
}