Ghana Science News API

{
    "totalArticles": 1580,
    "articles": [
        {
            "id": "492b0b1cb32483bfdb9bf89a188aa59b",
            "title": "Cell-to-cell variability and gain of methylation at polycomb CpG islands as a hallmark of aging",
            "description": "Aging is a complex multifactorial process that affects cellular function and tissue homeostasis over time. Despite substantial research, the molecular mechanisms driving cellular aging remain poorly understood. Many studies focused on changes in DNA methylation as an indicator of aging. In particular, methylation at polycomb CpG islands was shown to be predictive of phenotypic changes associated with aging. Since many age-related pathological processes are thought to originate from single cells, we asked whether polycomb CpG island methylation occurs preferentially in a subset of cells within a population. Using single-cell whole-genome methylation data across ages and tissues, we identify polycomb CpG methylation as a hallmark of cellular aging. This revealed that aging occurs at varying rates, with faster proliferating cells showing accelerated gain of methylation. Differential gene expression analysis identified changes in immune response, translation, tumorigenesis and neurodegeneration. These results challenge traditional models of homogeneous cellular aging and suggest that aging is a highly individualized process at the single-cell level, that may be driven by programmed changes in polycomb CpG island DNA methylation. Aging is associated with DNA methylation changes, but how this occurs in individual cells is unclear. Here, the authors show that methylation at polycomb CpG islands accumulates unevenly across single cells, revealing that some cells age faster than others.",
            "content": "Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give... [797 chars]",
            "url": "https://www.nature.com/articles/s41467-026-74118-5?error=cookies_not_supported&code=708f488a-ec68-46d5-b3c1-01eb0936d63d",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-06-09T18:33:45Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "b58cfa61f87f124decba52163092a003",
            "title": "Scientists think they solved the mystery of the Amaterasu particle",
            "description": "The mysterious Amaterasu particle may not be a proton at all. New research suggests that some of the most extreme cosmic rays could be ultraheavy atomic nuclei, heavier than iron, which are better able to retain their energy while traveling through space. This idea could help explain how these rare particles reach Earth and provide new clues about the powerful cosmic explosions that create them.",
            "content": "Ultrahigh-energy cosmic rays are particles from space that slam into Earth with energies far beyond anything produced by human-built particle accelerators. Among the most extraordinary examples is the \"Amaterasu particle,\" which was detected by the T... [5550 chars]",
            "url": "http://www.sciencedaily.com/releases/2026/06/260608040015.htm",
            "image": "https://www.sciencedaily.com/images/1920/murase-ultrahigh-energy-cosmic-rays.webp",
            "publishedAt": "2026-06-09T11:19:58Z",
            "lang": "en",
            "source": {
                "id": "8400452cd3ae520c3deec87e0653d197",
                "name": "ScienceDaily",
                "url": "http://www.sciencedaily.com"
            }
        },
        {
            "id": "7da9aa79af13f56a0e492cbea85b742e",
            "title": "Geoscientists Find Vast Fan-Shaped Structure beneath Antarctica’s Ice",
            "description": "By combining seismic, gravity and topographic data, a team of researchers from Italy, Switzerland, Germany and the United Kingdom found that several well-known subglacial basins in East Antarctica are part of a single fan-shaped province whose origins trace back to ancient continental stretching.",
            "content": "By combining seismic, gravity and topographic data, a team of researchers from Italy, Switzerland, Germany and the United Kingdom found that several well-known subglacial basins in East Antarctica are part of a single fan-shaped province whose origin... [2790 chars]",
            "url": "https://www.sci.news/othersciences/geoscience/east-antarctic-fan-shaped-basin-province-14826.html",
            "image": "https://cdn.sci.news/images/2026/06/image_14826-East-Antarctica.jpg",
            "publishedAt": "2026-06-08T15:21:48Z",
            "lang": "en",
            "source": {
                "id": "c74358087a9ef7a865a623801c9a631c",
                "name": "Sci.News",
                "url": "https://www.sci.news"
            }
        }
    ]
}