United States Science News API

{
    "totalArticles": 46274,
    "articles": [
        {
            "id": "1ed17b837077ab1574291f1d67d5e97e",
            "title": "Every year, 27.7 million tons of Saharan dust crosses the Atlantic Ocean and settles on the Amazon rainforest, delivering roughly the exact amount of phosphorus the rainforest loses to runoff, which m",
            "description": "The connection is one of those facts about the planet that nobody designed and almost no one outside the relevant atmospheric science literature knows about. Every year, somewhere between 180 and 200 million tons of fine particulate dust gets picked up from the Sahara Desert by trade winds, lifted into the upper atmosphere, and carried […]",
            "content": "The connection is one of those facts about the planet that nobody designed and almost no one outside the relevant atmospheric science literature knows about. Every year, somewhere between 180 and 200 million tons of fine particulate dust gets picked ... [8484 chars]",
            "url": "https://spacedaily.com/k-every-year-27-7-million-tons-of-saharan-dust-crosses-the-atlantic-ocean-and-settles-on-the-amazon-rainforest-delivering-roughly-the-exact-amount-of-phosphorus-the-rainforest-loses-to-runoff-which-m/",
            "image": "https://spacedaily.com/wp-content/uploads/2026/05/tr-2026-05-20T183705.675.png",
            "publishedAt": "2026-05-20T23:00:07Z",
            "lang": "en",
            "source": {
                "id": "e78ce7d66fa4cc7a845a221fd1505b06",
                "name": "Space Daily",
                "url": "https://spacedaily.com"
            }
        },
        {
            "id": "b2c522d2a737cab733c83276f51198fc",
            "title": "Lanzado el satélite SMILE de China y la ESA para estudiar la interacción entre el Sol y la Tierra",
            "description": "La colaboración entre China y Europa occidental en materia espacial ha disminuido en los últimos años, pero no ha desaparecido. Un ejemplo es la misión SMILE, desarrollada conjuntamente entre la […]",
            "content": "La colaboración entre China y Europa occidental en materia espacial ha disminuido en los últimos años, pero no ha desaparecido. Un ejemplo es la misión SMILE, desarrollada conjuntamente entre la Agencia Espacial Europea y la República Popular China, ... [4740 chars]",
            "url": "https://danielmarin.naukas.com/2026/05/21/lanzado-el-satelite-smile-de-china-y-la-esa-para-estudiar-la-interaccion-entre-el-sol-y-la-tierra/",
            "image": "https://danielmarin.naukas.com/files/2026/05/HIp7sMfWsAAyQPm.jpeg",
            "publishedAt": "2026-05-20T22:35:34Z",
            "lang": "es",
            "source": {
                "id": "279451ac73e4588587a026fc5bce0dad",
                "name": "Naukas",
                "url": "https://danielmarin.naukas.com"
            }
        },
        {
            "id": "1a9bb6f8f9cdb8c4f4b5ce999e81c535",
            "title": "Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite",
            "description": "l-2-Hydroxyglutarate (l-2-HG) is a low-abundance metabolite in mammals because the mitochondrial enzyme l-2-HG dehydrogenase (L2HGDH) oxidizes l-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation1. In humans, a lack of L2HGDH activity leads to l-2-HG accumulation and causes l-2-hydroxyglutaric aciduria2. Thus, l-2-HG is often classified as a toxic metabolite2–5. However, whether l-2-HG has any physiological function is unclear. Here we investigate whether l-2-HG qualifies as a physiological signalling metabolite by testing three criteria: regulated levels, defined molecular targets and a measurable physiological function. We report that an increase in mitochondrial NADH/NAD+ ratio drives malate dehydrogenase 2 (MDH2) to reduce 2-OG into l-2-HG. Moreover, L2HGDH oxidizes l-2-HG back to 2-OG in the mitochondrial matrix without requiring a functional electron transport chain. Through proteome integral solubility alteration assays, we show that the KDM4 family of H3K9 demethylases are l-2-HG-responsive targets. l-2-HG represses the nascent transcription of specific genes in mouse embryonic stem cells and increases H3K9me3 (a repressive histone mark) at these loci. In vivo, early embryonic L2HGDH overexpression in mice systemically reduces l-2-HG levels, impairs postnatal growth, causes mortality and produces selective functional and histological renal vulnerabilities. In postnatal kidneys, this reduction in l-2-HG causes H3K9me3 loss at L1MdTf retrotransposons and their derepression, which coincides with the activation of the integrated stress response and inflammation pathways. Our findings establish mitochondrial l-2-HG as a physiological signalling metabolite and indicate that metabolites previously regarded as toxic may also have crucial physiological functions. l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and function.",
            "content": "Cell culture, drug treatment and fractionation\n143B cells were cultured in Dulbecco’s modified Eagle medium (DMEM) (Gibco, 11965-126) supplemented with 10% Nu-serum IV (Corning, 355504), 10 mM HEPES (Corning, 25-060-CI), 1× GlutaMAX (Gibco, 35050061)... [47094 chars]",
            "url": "https://www.nature.com/articles/s41586-026-10564-x?error=cookies_not_supported&code=5a3b6eb0-66cd-49b8-ad8b-6e1d943b7650",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41586-026-10564-x/MediaObjects/41586_2026_10564_Fig1_HTML.png",
            "publishedAt": "2026-05-20T21:45:00Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        }
    ]
}