Singapore Science News API

{
    "totalArticles": 15872,
    "articles": [
        {
            "id": "00af2ba23e69e2476fed7661355b4672",
            "title": "Bacterial Schlafen proteins mediate phage defence",
            "description": "Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of life, its function in prokaryotes has remained unclear. Here we demonstrate that prokaryotic Schlafen nucleases are widespread antiviral effectors that protect bacteria from bacteriophages and are fused to a diverse array of phage-sensing domains. We expressed seven Enterobacterales Schlafen systems in Escherichia coli, identifying two that confer defence against coliphages. We focused on a system where Schlafen nuclease is fused to a previously unknown immunoglobulin-like sensor domain and demonstrated that it recognizes tail assembly chaperones of T5-like phages. Upon activation, the Schlafen nuclease cleaves both E. coli and phage-encoded tRNAs and restricts T5 phage by reducing its burst size. Our findings redefine Schlafens as an ancient, mechanistically conserved family of immune effectors, revealing the deep evolutionary origin of tRNA-targeting antiviral immunity in humans. This study highlights that Schlafens are ancient, mechanistically conserved immune effectors that mediate antiviral immunity in organisms ranging from humans to bacteria.",
            "content": "The human SLFN11 protein has an N-terminal ribonuclease (RNase) domain, a linker domain and a C-terminal DNA/RNA helicase domain4. The N-terminal domain consists of two lobes (N- and C-lobe), where the C-lobe contains the ribonuclease active site wit... [44078 chars]",
            "url": "https://www.nature.com/articles/s41564-026-02277-8?error=cookies_not_supported&code=5887ebd5-fbb8-4f8d-9895-626d0acddecd",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41564-026-02277-8/MediaObjects/41564_2026_2277_Fig1_HTML.png",
            "publishedAt": "2026-03-09T14:57:36Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "ca3ec43465d291b34aced679c8df74b9",
            "title": "Temple researchers help uncover and restore massive cold-water coral reef in Argentina",
            "description": "Erik Cordes, professor and chair of the Department of Biology, and PhD candidate Morgan Will are part of a deep-sea research project in Argentina focused on discovering and restoring largely unknown cold-water coral reefs.",
            "content": "The Great Barrier Reef is a vast, colorful ecosystem teeming with underwater life. It is the largest shallow water reef in the world and a household name. But scattered across the planet, up to a mile beneath the ocean’s surface, exists a more myster... [5167 chars]",
            "url": "https://now.temple.edu/news/2026-03-09/temple-researchers-help-uncover-restore-massive-cold-water-coral-reef-argentina",
            "image": "https://now.temple.edu/sites/now/files/styles/tu_image_style_open_graph/public/media/image/FKt251206-S0886-20251225T025447Z-0-scicam-CoralRock_0.jpg?h=b1b891d2&itok=9alCSEDL",
            "publishedAt": "2026-03-09T14:17:08Z",
            "lang": "en",
            "source": {
                "id": "36c3737b6cf5498f99f22e99f3297800",
                "name": "Temple University",
                "url": "http://news.temple.edu"
            }
        },
        {
            "id": "e148354735cd0e13f5932103132bc4c9",
            "title": "Brain network predicts how quickly we adapt to social behavior",
            "description": "Humans often adapt their behavior to that of other people with lightning speed. A new study by the University of Zurich reveals what brain networks govern social mentalization and adaptation, making it possible to predict how flexibly one person reacts to others.",
            "content": "Humans often adapt their behavior to that of other people with lightning speed. A new study by the University of Zurich reveals what brain networks govern social mentalization and adaptation, making it possible to predict how flexibly one person reac... [3538 chars]",
            "url": "https://www.news-medical.net/news/20260309/Brain-network-predicts-how-quickly-we-adapt-to-social-behavior.aspx",
            "image": "https://www.news-medical.net/image-handler/picture/2016/3/Artificially_Colored_MRI_Scan_Of_Human_Brain-Daisy_Daisy_a8c5d8bbbf824bc8932308e30187510f-620x480.jpg",
            "publishedAt": "2026-03-09T11:26:00Z",
            "lang": "en",
            "source": {
                "id": "f2ca7a45d20357cb42858868cb4a4946",
                "name": "News-Medical",
                "url": "https://www.news-medical.net"
            }
        }
    ]
}