Singapore Health News API

{
    "totalArticles": 48546,
    "articles": [
        {
            "id": "0f58b1e2194475daf392bcd695bd43df",
            "title": "Injury and therapy in a human spinal cord organoid",
            "description": "Damage to the spinal cord can lead to irreversible paralysis and loss of sensory function, but translation of preclinical therapies remains elusive. We recently showed that bioactive supramolecular assemblies of peptide amphiphiles can reverse paralysis in an acute mouse model following severe spinal cord injury (SCI). Here we report the development of two human spinal cord organoid injury models to simulate SCI in vitro, a laceration of the organoid with a scalpel and a compressive contusion commonly used in preclinical models, both resulting in immediate neuronal death and the formation of glial scar-like tissue. Treatment of the injured organoids with the preclinical therapy suppressed the scar-like tissue and promoted significant axonal regeneration, as observed previously in vivo. With the inclusion of microglia into the spinal cord organoids, we demonstrate that the supramolecular nanomaterial reduced pro-inflammatory factors commonly associated with injury. The human spinal cord organoid models developed here could accelerate the discovery of therapies to treat SCI and possibly damage of other central nervous system tissues owing to trauma or disease. A human spinal cord organoid model can replicate two different types of spinal cord injury and can be used as an in vitro system to evaluate therapeutics and inflammatory reactions to treatments.",
            "content": "Research funding was provided by the Center for Regenerative Nanomedicine at Northwestern University and a gift from the John Potocsnak Family for spinal cord injury research. Peptide amphiphile synthesis was performed at the Peptide Synthesis Core F... [4367 chars]",
            "url": "https://www.nature.com/articles/s41551-025-01606-2?error=cookies_not_supported&code=fcb993fa-d59b-48ac-a888-d35791b1276a",
            "image": "https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41551-025-01606-2/MediaObjects/41551_2025_1606_Fig1_HTML.png",
            "publishedAt": "2026-02-11T11:21:32Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "3cd36e40aa18a2151ac7d58aece071bc",
            "title": "Heart disease risk factors appeared at younger age among South Asian adults in the U.S.",
            "description": "Both middle‑aged South Asian men and women had higher rates of prediabetes, Type 2 diabetes and high blood pressure compared to white, Chinese and Hispanic peers, and similar or slightly lower rates of high blood pressure compared to Black adults despite healthier lifestyles, according to a new study in the Journal of the American Heart Association.",
            "content": "Research Highlights:\nSouth Asian adults begin developing risk factors for heart disease earlier—by their mid-40s—according to an analysis of data from two long-running health studies in the United States.\nDespite healthier lifestyle/behaviors, such a... [9163 chars]",
            "url": "https://newsroom.heart.org/news/heart-disease-risk-factors-appeared-at-younger-age-among-south-asian-adults-in-the-u-s",
            "image": "https://iprsoftwaremedia.com/67/files/20179/59f3431e2cfac22ba70b5c27_Heart%20chambers%20illustration/Heart%20chambers%20illustration_hero.jpg",
            "publishedAt": "2026-02-11T10:04:02Z",
            "lang": "en",
            "source": {
                "id": "6cacf118472bb930a32eb54ae379a24b",
                "name": "www.heart.org",
                "url": "https://newsroom.heart.org"
            }
        },
        {
            "id": "591db0b9ddc534ff42c4d46a6b6d8178",
            "title": "Criteria to Assess the Predictive and Clinical Utility of Cardiovascular Disease",
            "description": "This Scientific Statement provides an updated framework for the critical appraisal of the predictive and clinical utility of novel biomarkers, models, and tools and builds upon the previously published AHA Scientific Statement on the “Criteria for Evaluation of Novel Markers of Cardiovascular Risk”.",
            "content": "This Scientific Statement provides an updated framework for the critical appraisal of the predictive and clinical utility of novel biomarkers, models, and tools and builds upon the previously published AHA Scientific Statement on the “Criteria for Ev... [581 chars]",
            "url": "https://professional.heart.org/en/science-news/criteria-to-assess-the-predictive-and-clinical-utility-of-cardiovascular-disease",
            "image": "https://professional.heart.org/-/media/PHD-Images/Science-News/k/khan_figure_750x500.png?sc_lang=en&hash=B36122A2BDD18AE96CD523522C344916",
            "publishedAt": "2026-02-11T10:03:23Z",
            "lang": "en",
            "source": {
                "id": "2ec6468e5ebcced6325056fe3120bfa1",
                "name": "professional.heart.org",
                "url": "https://professional.heart.org"
            }
        }
    ]
}