Ireland Health News API

{
    "totalArticles": 185332,
    "articles": [
        {
            "id": "bd51613e220b5948dd9e8eadcf97ce19",
            "title": "Drop in numbers presenting to hospital EDs with flu",
            "description": "There has been a reduction in the number of people presenting to emergency departments with Influenza, the Health Service Executive has said.",
            "content": "There has been a reduction in the number of people presenting to emergency departments with influenza, the Health Service Executive (HSE) has said.\nIt comes after the HSE warned that flu cases are likely to peak during Christmas week.\nIn a statement ... [1562 chars]",
            "url": "https://www.rte.ie/news/health/2025/1222/1550212-flu-numbers/",
            "image": "https://www.rte.ie/images/001e5775-1600.jpg",
            "publishedAt": "2025-12-22T15:31:20Z",
            "lang": "en",
            "source": {
                "id": "8bcb1c163b5eb62b4cdfdafb99503799",
                "name": "RTE.ie",
                "url": "https://www.rte.ie"
            }
        },
        {
            "id": "84a0e8bb36f5b936014fb52eb8eff540",
            "title": "Winter exposes how closely eczema, asthma and allergies are linked",
            "description": "Winter exacerbates atopic dermatitis in children, but effective management strategies and new treatments offer hope for improved skin health and comfort.",
            "content": "Atopic dermatitis (AD), or eczema, is one of the most common chronic skin conditions in children, and for many families it becomes harder to manage as colder weather sets in.\nDuring the winter months, children tend to spend more time indoors, which i... [4376 chars]",
            "url": "https://www.managedhealthcareexecutive.com/view/winter-exposes-how-closely-eczema-asthma-and-allergies-are-linked",
            "image": "https://cdn.sanity.io/images/0vv8moc6/mhe/deb839adbf738e6811ef3a2d0f4663a42e4602d2-4200x2800.jpg",
            "publishedAt": "2025-12-22T13:07:44Z",
            "lang": "en",
            "source": {
                "id": "214cca6a08061d4cdb1f485b50433990",
                "name": "Managed Healthcare Executive",
                "url": "https://www.managedhealthcareexecutive.com"
            }
        },
        {
            "id": "9519fd868755ecf3f5f0ef6d7ff30920",
            "title": "Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk",
            "description": "Flaviviruses are a family of related viruses that cause substantial global morbidity and mortality. Vaccination against one flavivirus can sometimes exacerbate disease caused by related viruses through antibody-dependent enhancement (ADE) or interfere with the efficacy of subsequent vaccines. To address this challenge, we develop a vaccine strategy by introducing G5C/G102C mutations into the flavivirus envelope (E) glycoprotein. These mutations promote E dimerization through the formation of an inter-chain disulfide bond that conceals the immunodominant and ADE-prone fusion loop epitope (FLE). We validate this design on E proteins from multiple flaviviruses through biochemical, antigenic, and structural analyses. The resulting vaccine candidate, CC_FLE sE, derived from the Zika virus (ZIKV) and formulated with an advanced supramolecular adjuvant, provides significant protection in female mice challenged with ZIKV and prevents ADE caused by a related flavivirus, Dengue virus. In genetically modified mice expressing diverse human immunoglobulin loci, ZIKV CC_FLE sE induces robust neutralizing antibody responses targeting key ZIKV E protein epitopes, including the E-dimer–dependent epitope (EDE), indicating that ZIKV CC_FLE sE can elicit protective antibody responses within the human naïve B cell repertoire. Therefore, CC_FLE sE represents a promising strategy for developing flavivirus vaccines that minimize ADE risk while maintaining high protective efficacy. In this study, the authors develop a flavivirus vaccine strategy by introducing mutations into envelope glycoproteins resulting in structural changes that conceal the ADE-prone fusion loop epitope. They show that the Zika virus-specific construct protects mice against viral challenge and prevents ADE by Dengue virus.",
            "content": "Pierson, T. C. & Diamond, M. S. The continued threat of emerging flaviviruses. Nat. Microbiol. 5, 796–812 (2020).\nDiamond, M. S., Ledgerwood, J. E. & Pierson, T. C. Zika Virus vaccine development: progress in the face of new challenges. Annu. Rev. Me... [16015 chars]",
            "url": "https://www.nature.com/articles/s41467-025-67447-4?error=cookies_not_supported&code=10a9a3eb-2aaa-4f78-9c2d-b5bb99548e15",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2025-12-22T12:24:28Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        }
    ]
}